ID   PRL_PROAT               Reviewed;         200 AA.
AC   P33091;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
GN   Name=prl;
OS   Protopterus aethiopicus (Marbled lungfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Dipnomorpha; Ceratodontiformes; Lepidosirenoidei; Protopteridae;
OC   Protopterus.
OX   NCBI_TaxID=7886;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=8329446; DOI=10.1016/0167-4838(93)90243-k;
RA   Noso T., Nicoll C.S., Kawauchi H.;
RT   "Lungfish prolactin exhibits close tetrapod relationships.";
RL   Biochim. Biophys. Acta 1164:159-165(1993).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; S34604; S34604.
DR   AlphaFoldDB; P33091; -.
DR   SMR; P33091; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Secreted.
FT   CHAIN           1..200
FT                   /note="Prolactin"
FT                   /id="PRO_0000181326"
FT   DISULFID        4..11
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..175
FT                   /evidence="ECO:0000250"
FT   DISULFID        192..200
FT                   /evidence="ECO:0000250"
FT   VARIANT         22
FT                   /note="R -> F"
FT   VARIANT         41
FT                   /note="F -> G"
SQ   SEQUENCE   200 AA;  22904 MW;  BEBA3E99B300443B CRC64;
     LPICANGSTN CHQIPLDDLF ERVVKLAHRI HSLTSDMFNE FDERYAQGRG FISRAINNCH
     TSSLTTPEDK EQAQKFHHDD LLRLVMKVLR SWNDPLLQLV SEVPQGIGEA PGTILWKVTE
     VEDQTKQLIE GMEKILGRMH PNGLDNEVLS LWPMPMAMHA GDGSKLFAFY NLLHCFRRDS
     FKIDSYLKLL RCRLFHEGGC