ID   PRL_RABIT               Reviewed;         227 AA.
AC   Q28632;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=PRL;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white;
RX   PubMed=8672230; DOI=10.1677/jme.0.0160027;
RA   Gabou L., Boisnard M., Gourdou I., Jammes M., Dulor J.P., Djiane J.;
RT   "Cloning of rabbit prolactin cDNA and prolactin gene expression in the
RT   rabbit mammary gland.";
RL   J. Mol. Endocrinol. 16:27-37(1996).
RN   [2]
RP   3D-STRUCTURE MODELING.
RX   PubMed=9094747;
RX   DOI=10.1002/(sici)1097-0134(199703)27:3<459::aid-prot13>3.0.co;2-k;
RA   Halaby D., Thoreau E., Djiane J., Mornon J.-P.;
RT   "Homology modeling of rabbit prolactin hormone complexed with its
RT   receptor.";
RL   Proteins 27:459-468(1997).
CC   -!- FUNCTION: Prolactin acts primarily on the mammary gland by promoting
CC       lactation.
CC   -!- SUBUNIT: Interacts with PRLR. {ECO:0000250|UniProtKB:P01236}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; U27199; AAB17481.1; -; mRNA.
DR   RefSeq; NP_001076144.1; NM_001082675.1.
DR   AlphaFoldDB; Q28632; -.
DR   SMR; Q28632; -.
DR   BioGRID; 1172414; 1.
DR   STRING; 9986.ENSOCUP00000001120; -.
DR   PRIDE; Q28632; -.
DR   GeneID; 100009394; -.
DR   KEGG; ocu:100009394; -.
DR   CTD; 5617; -.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   InParanoid; Q28632; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Lactation; Phosphoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..227
FT                   /note="Prolactin"
FT                   /id="PRO_0000032924"
FT   MOD_RES         54
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         62
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   MOD_RES         118
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01239"
FT   DISULFID        32..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        86..202
FT                   /evidence="ECO:0000250"
FT   DISULFID        219..227
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   227 AA;  25990 MW;  74B7570F4F7DB048 CRC64;
     MDSKWSRRTG SLLLLLVSNL LLCKSTASLP ICPSGAVNCQ VSLRDLFDRA VILSHHIHKL
     SSEMFNEFDK RYTQGRGFIT KAINSCHTSS LSTPEDKEQA QQIHHEDLLN MVLRVLPSWN
     DPLYHLVTEV RGMQEAPDAI LSKAIEIEEQ NRRLLEGMEK IVGQVHPGIK ENEIYSVWSG
     LPSLQMADED ARLFAFYNLL HCLRRDSHKI DNYLKLLKCR IIYDSNC