ID   ATG16_YEAS7             Reviewed;         150 AA.
AC   A6ZML8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Autophagy-related protein 16;
DE   AltName: Full=Cytoplasm to vacuole targeting protein 11;
DE   AltName: Full=SAP18 homolog;
GN   Name=ATG16; Synonyms=APG15, APG16, CVT11, SAP18; ORFNames=SCY_4334;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Stabilizes the ATG5-ATG12 conjugate and mediates the
CC       formation of the 350 kDa complex, which is necessary for autophagy. The
CC       ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-
CC       conjugation to phosphatidylethanolamine and ATG8 localization to the
CC       pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS.
CC       Involved in endoplasmic reticulum-specific autophagic process and is
CC       essential for the survival of cells subjected to severe ER stress (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Part of the 350 kDa complex which is at least
CC       composed of ATG5, ATG12 and ATG16. Several units of each may be present
CC       in this complex. Interacts directly with ATG12. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000250|UniProtKB:Q03818}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q03818}.
CC   -!- SIMILARITY: Belongs to the ATG16 family. {ECO:0000305}.
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DR   EMBL; AAFW02000021; EDN64092.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZML8; -.
DR   SMR; A6ZML8; -.
DR   EnsemblFungi; EDN64092; EDN64092; SCY_4334.
DR   HOGENOM; CLU_158825_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR   Pfam; PF08614; ATG16; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Membrane; Protein transport; Transport.
FT   CHAIN           1..150
FT                   /note="Autophagy-related protein 16"
FT                   /id="PRO_0000317978"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          61..130
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        7..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   150 AA;  17222 MW;  6D4308298D4DBB59 CRC64;
     MGNFIITERK KAKEERSNPQ TDSMDDLLIR RLTDRNDKEA HLNELFQDNS GAIGGNIVSH
     DDALLNTLAI LQKELKSKEQ EIRRLKEVIA LKNKNTERLN DELISGTIEN NVLQQKLSDL
     KKEHSQLVAR WLKKTEKETE AMNSEIDGTK