ID   PRL_SALSA               Reviewed;         210 AA.
AC   P48096;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=prl;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RA   Martin S.A.M., Ferguson A., Youngson A.F.;
RL   Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 24-48, AND CHARACTERIZATION.
RC   TISSUE=Pituitary;
RX   PubMed=2925076; DOI=10.1016/0016-6480(89)90191-3;
RA   Andersen O., Skibeli V., Gautvik K.M.;
RT   "Purification and characterization of Atlantic salmon prolactin.";
RL   Gen. Comp. Endocrinol. 73:354-360(1989).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; X84787; CAA59258.1; -; mRNA.
DR   PIR; A60619; A60619.
DR   PIR; S52475; S52475.
DR   RefSeq; NP_001117140.1; NM_001123668.1.
DR   AlphaFoldDB; P48096; -.
DR   SMR; P48096; -.
DR   STRING; 8030.ENSSSAP00000063821; -.
DR   GeneID; 100136580; -.
DR   KEGG; sasa:100136580; -.
DR   CTD; 5617; -.
DR   OMA; SALMCKA; -.
DR   OrthoDB; 1290070at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa03.
DR   Bgee; ENSSSAG00000057719; Expressed in brain and 5 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0005148; F:prolactin receptor binding; ISS:AgBase.
DR   GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IDA:AgBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISS:AgBase.
DR   GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; IDA:AgBase.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IDA:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
DR   GO; GO:0070665; P:positive regulation of leukocyte proliferation; ISS:AgBase.
DR   GO; GO:1903592; P:positive regulation of lysozyme activity; IDA:AgBase.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IDA:AgBase.
DR   GO; GO:1900182; P:positive regulation of protein localization to nucleus; IDA:AgBase.
DR   GO; GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IDA:AgBase.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IDA:AgBase.
DR   GO; GO:0060267; P:positive regulation of respiratory burst; IDA:AgBase.
DR   GO; GO:0032930; P:positive regulation of superoxide anion generation; IDA:AgBase.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:AgBase.
DR   GO; GO:0002637; P:regulation of immunoglobulin production; ISS:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:2925076"
FT   CHAIN           24..210
FT                   /note="Prolactin"
FT                   /id="PRO_0000032947"
FT   DISULFID        69..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..210
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  23396 MW;  6BD49046486E0A34 CRC64;
     MARRSQGTKL HLAVLCLVVS CHAIGLSDLM ERASQRSDKL HSLSTSLTKD LDSHFPPMGR
     VMMPRPSMCH TSSLQTPKDK EQALKVSENE LISLARSLLL AWNDPLLLLS SEAPTLPHPS
     NGDISSKIRE LQDYSKSLGD GLDIMVNKMG PSSQYISSIP FKGGDLGNDK TSRLINFHFL
     MSCFRRDSHK IDSFLKVLRC RATKMRPETC