ID   PRL_SPAAU               Reviewed;         212 AA.
AC   O93337;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Prolactin;
DE            Short=PRL;
DE   Flags: Precursor;
GN   Name=prl;
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Sparus.
OX   NCBI_TaxID=8175;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=10094859; DOI=10.1006/gcen.1998.7228;
RA   Santos C.R.A., Brinca L., Ingleton P.M., Power D.M.;
RT   "Cloning, expression, and tissue localisation of prolactin in adult sea
RT   bream (Sparus aurata).";
RL   Gen. Comp. Endocrinol. 114:57-66(1999).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF060541; AAC26852.1; -; mRNA.
DR   AlphaFoldDB; O93337; -.
DR   SMR; O93337; -.
DR   Proteomes; UP000472265; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..212
FT                   /note="Prolactin"
FT                   /id="PRO_0000032948"
FT   DISULFID        70..185
FT                   /evidence="ECO:0000250"
FT   DISULFID        202..212
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   212 AA;  23338 MW;  65DF453E1D57F185 CRC64;
     MAHRETNGSK LFITVLCMVA ACSAVPINDL LDRASQRSDM LHSLSTTLTK DLSNHVPPVG
     WTMMPRPPLC HTSSLQTPND KEQALQLSES DLMSLARSLL QAWQDPLVDL SNSANSLLHP
     SQSSISNKIR ELQEHSKSLG DGLDILSGKM GPAAQAISSL PYRGSNDIGE DNISKLTNFH
     FLLSCFRRDS HKIDSFLKVL RCRAAKVQPE MC