ID   PRM10_ASHGO             Reviewed;         740 AA.
AC   Q754J7;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Pheromone-regulated membrane protein 10;
GN   OrderedLocusNames=AFR075C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ThrE exporter (TC 2.A.79) family.
CC       {ECO:0000305}.
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DR   EMBL; AE016819; AAS53446.1; -; Genomic_DNA.
DR   RefSeq; NP_985622.1; NM_210976.1.
DR   AlphaFoldDB; Q754J7; -.
DR   STRING; 33169.AAS53446; -.
DR   EnsemblFungi; AAS53446; AAS53446; AGOS_AFR075C.
DR   GeneID; 4621864; -.
DR   KEGG; ago:AGOS_AFR075C; -.
DR   eggNOG; ENOG502QPMM; Eukaryota.
DR   HOGENOM; CLU_007078_1_1_1; -.
DR   InParanoid; Q754J7; -.
DR   OMA; PGFTMCL; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR010619; ThrE.
DR   InterPro; IPR024528; ThrE_2.
DR   Pfam; PF06738; ThrE; 1.
DR   Pfam; PF12821; ThrE_2; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..740
FT                   /note="Pheromone-regulated membrane protein 10"
FT                   /id="PRO_0000409249"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        445..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        475..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        499..519
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        541..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        574..594
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        599..619
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        622..642
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        651..671
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        707..727
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          65..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  80702 MW;  515CBF21E0FC3474 CRC64;
     MGKNKKQAAE GEEARRGSES SGSSAEPSGA VAELPSFKKT AGGARSGLIE QDAVDTIREQ
     TAVKFADEDE VVEQDEAAQK TEAVASESSS LADKEECDES KLDHFRKFFR RTSSRSSDEG
     EGGGMMERFI NMTGGGMVPV VTEAPEEDEE AGPDPTAEAE AAAREIMKAH HLSSGQSVDM
     MSMSSSGESG FFMPVAEHYD DEYNPEQEEE QRDDMSEATY VPPPQHVRGG VLGSLLRLYQ
     NQPGGQAPQR PGLRKSAQTL SSETLPTGES YEMPKFKAKR PRGSKIPNPI KLKRKSAMSE
     ARITVHIADL LQRHRFILRL CKAFMMYGAP THRLEEYMVM TSRVLEIDSQ FLYLPGCMVV
     SFGDTITRTS EVQLVRCSQG LNLWKLHQVH SIYKQVVHDI ISVEDASRTI ETIMAEKNLY
     PAWMCVLLYG FCASMVTPFA FGGDWINLVV SFGIGCCVGL LQFIVAQRSH VYSNVFEITA
     SIVVSFCARA LGSIPNSNIC FGSTVQGSLA LILPGYIILC GSLELQSRSL VAGSVRMFYA
     IIYSLFLGFG ITLGAALFGW IYRDATNETV CEKELSPWFR FIFVPGFALG LSLINQARWS
     QIPVMVCIAC SGYVVTYWSG QHFTASTEFT ASIGAFVIGI MGNLYSRIWK GLAMTAMLPG
     IFVQVPSGIA SKSTLLSSVQ SANNMVSNGT NAAVNSVDGR TSISFGITMI QVCIGISVGL
     FASTLVVYPF GKKRTGLFTL