PRM10_CANAW
ID PRM10_CANAW Reviewed; 1105 AA.
AC C4YTQ0;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 35.
DE RecName: Full=Pheromone-regulated membrane protein 10;
GN ORFNames=CAWG_05545;
OS Candida albicans (strain WO-1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294748;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-1;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ThrE exporter (TC 2.A.79) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000313; EEQ46991.1; -; Genomic_DNA.
DR AlphaFoldDB; C4YTQ0; -.
DR STRING; 5476.C4YTQ0; -.
DR TCDB; 2.A.79.1.10; the threonine/serine exporter (thre) family.
DR PRIDE; C4YTQ0; -.
DR EnsemblFungi; EEQ46991; EEQ46991; CAWG_05545.
DR VEuPathDB; FungiDB:CAWG_05545; -.
DR HOGENOM; CLU_007078_1_0_1; -.
DR OMA; FVYFPGT; -.
DR Proteomes; UP000001429; Chromosome 7.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR010619; ThrE.
DR InterPro; IPR024528; ThrE_2.
DR Pfam; PF06738; ThrE; 1.
DR Pfam; PF12821; ThrE_2; 1.
PE 3: Inferred from homology;
KW Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..1105
FT /note="Pheromone-regulated membrane protein 10"
FT /id="PRO_0000409251"
FT TRANSMEM 782..802
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 809..829
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 835..855
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 860..880
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 903..923
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 938..958
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 963..983
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 986..1006
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1015..1035
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1075..1095
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 36..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1105 AA; 120738 MW; 816C0448D6A8670D CRC64;
MSDNRPTYDT SSSDEEPSNH FHIQLPQRQL NLQEIRKQNH KKHEKPTIAK QTASNLAKAK
KITTGSNHKF GNSINNNNNN ANKHLGSSSA GTNRRSLISP TSSTHVSSDD DDDDDDNAAF
YGDKLNDNKK LNVFADTKNN LSHFQFNADG IKPKSLHGQG DDSSDDDGNN LDEVEDETHS
DFAVLNQNHP PQQYYETDSS DEDEEDDDEV PQTVHKTYSN ASSGRSSRLS RKKSMSETTD
TRAPIPPTGR RSTNSNHSRE SSGRRSTSSG NINSGGGLKG ILRKMSLVDS TPVDSTNQDI
SHSDTFLGRV LNFGTNQGLS GGGLAPGASR VIREEDEGEW NLDEERRVGF AAHENDRDAF
EMQPLNYEDL SEEAKQLIQQ HVPGAGASNL DHSQQSSAAP STEITPSQSP NQHLLNEKSN
NNENNQQSTT VESSSSTSSP GEDEELARRR ASEERKKAEN PFYTPNPDLF LRGTNADNQE
LHQAPNDFLH DMDGDYIAPP KQVQAGVLSS LLRLYQNPQE QKSASSLSRV STGTSGTALS
SFDDSYDSDD YKDSKSSSNV DLQHKLKSGI KGGSKAMFNK AANKLKHHSH TRTNTVETQG
SSNSEEFSND KDEFSNGYDD DNKMNANLPS FQNARPKMPK KKTTEPVQKL KKLRHKQRAE
RLRITVHIAD ILQRQRFIMN MCRALMLFGA PTHRLEEYMV MTSRVLEIDG QFIYFPGCML
VSFGDAATRT SEVHLVRCAQ GINLSKLADT HKIYKAVIHD LIGVEDASKK LDDLLKSKSR
YPPWLCVLFY GLGSLAVTPF AFEGGWLDLP ISFGVGLCVG YLQFYVSSIS NLYSSVFEVS
AAIVVAFIAR GIGSIKGGDL FCFSAIAQGS LAIILPGYII LCGSLELQSR NLVAGAVRMF
YAVIYSLFLG FGITLGAALY GWIDHNATSA NSCASGHAID EKWRILFVPM FALCLGLINQ
ARWSQVPIMI VIAGIGYIGS FFAGKHFSTV TEFTACIGAF IVGVLGNLYS RIWKGMAVSA
MLPAIFVQVP SGIASKSSLI SGLNTADQIT NKSSSNNGGT VTNDASSLSF GATMVEVSIG
ISVGLFAAAL IIYPFGKKRT GLFAL
