PRM10_KLULA
ID PRM10_KLULA Reviewed; 951 AA.
AC Q6CLI2;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Pheromone-regulated membrane protein 10;
GN OrderedLocusNames=KLLA0F02816g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ThrE exporter (TC 2.A.79) family.
CC {ECO:0000305}.
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DR EMBL; CR382126; CAG97915.1; -; Genomic_DNA.
DR RefSeq; XP_455207.1; XM_455207.1.
DR AlphaFoldDB; Q6CLI2; -.
DR STRING; 28985.XP_455207.1; -.
DR EnsemblFungi; CAG97915; CAG97915; KLLA0_F02816g.
DR GeneID; 2896014; -.
DR KEGG; kla:KLLA0_F02816g; -.
DR eggNOG; ENOG502QPMM; Eukaryota.
DR HOGENOM; CLU_007078_1_1_1; -.
DR InParanoid; Q6CLI2; -.
DR OMA; MTLISCC; -.
DR Proteomes; UP000000598; Chromosome F.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR010619; ThrE.
DR InterPro; IPR024528; ThrE_2.
DR Pfam; PF06738; ThrE; 1.
DR Pfam; PF12821; ThrE_2; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..951
FT /note="Pheromone-regulated membrane protein 10"
FT /id="PRO_0000409254"
FT TRANSMEM 635..655
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 657..677
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 687..707
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 711..731
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 753..773
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 786..806
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 811..831
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 841..861
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 863..883
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 918..938
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 103482 MW; E86708788C3CD1CD CRC64;
MSSSYGNNGD KNNHEKFGFN LLRKKPQQPS NRSERRADDS SSSEDEAGPS SNYVSSSQLN
LPSFRPSGGS TDELNRANRT NVGSSDARYS PRTASNTESG NRRQQMIEDD AIATIRDNSG
AARCFDDDDE EEEEHQEQKD SGENPADISP RTSGVTKKLQ FKSHPSIIPE DTATQDGGEY
YEEKDAEKED QDDSVSTQSS ESKMDHFRHL FRRRSTARPH QETNDGRNSA ESHSKGGMRN
LNGADDEVED GGFLSKFLSL TGGGLTPAVN NTDPSGENDH ERNAGQNNLE DPIPMSDIAA
TAQQIVQAHS MMAGKSAPGT QHGASGSASS EHPNGEHNLG TEAGVTSPFE PVSPFNQSTD
GETMVSSHQD DAFYVPATNH YDDIDDPDDL EPLGIEGSYI APVDRVRGGV LGSLLKLYQN
QDDQYTKSQL SLNDSSIEQT PEPVDQAGKS DQKTGKKIYN PFHKHSKSQT NVSGANKSGS
SMNLPNFKAT RPKAAAKNLV KAKNFKKKAA AEARITVHIA DLLQRQRFIL RLCKALMLYG
APTHRLEEYM VMTSRVLEID GQFLYVPGCM IISFGDMTTR TSEVQLVRCN QGLNLWKLHG
VHSVYKQVVH DIMSVEDANM EIDRILTGKN LYPPWVSVLL YAFCSSMVTP FAFGGDWINM
AVAFGIGLCV GSLQFIVSQK SNLYSNVFEV TASIVVSFCG RALGSIPNSN ICFGATVQGS
LALILPGYII LCGSLELQSR NLVAGAVRMF YAIIYSLFLG FGITLGAALF GWIYHDATNE
TSCSKNISPW FRFIFVPCFS IGLGLINQAR WTQLPVMTLI SCCGYVVTYF SGKHFANSTE
FTSAMAAFVI GILGNLYSRI WKGFAVSAML PAIFVQVPSG VASQSSLLAG VQSANAIVNN
STTTVVQDDL SGSMSFGVTM IQVSIGISVG LFASTLFIYP FGKKRTGLFT L
