PRM10_PICSO
ID PRM10_PICSO Reviewed; 995 AA.
AC Q9UVG5; G8YU31;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Pheromone-regulated membrane protein 10;
GN ORFNames=GNLVRS01_PISO0A10120g, GNLVRS01_PISO0B10187g, Piso0_000473;
OS Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS 10061 / NRRL Y-12695) (Hybrid yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX NCBI_TaxID=559304;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL Y-12695;
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.-L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.-F., Sarkar A., Savel G., Schacherer J., Seret M.-L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.-L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-995.
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL Y-12695;
RX PubMed=11054818;
RX DOI=10.1002/1097-0061(200011)16:15<1377::aid-yea637>3.0.co;2-0;
RA Sychrova H., Braun V., Potier S., Souciet J.L.;
RT "Organization of specific genomic regions of Zygosaccharomyces rouxii and
RT Pichia sorbitophila: comparison with Saccharomyces cerevisiae.";
RL Yeast 16:1377-1385(2000).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ThrE exporter (TC 2.A.79) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB62252.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO082059; CCE72871.1; -; Genomic_DNA.
DR EMBL; FO082058; CCE73432.1; -; Genomic_DNA.
DR EMBL; Y18559; CAB62252.1; ALT_FRAME; Genomic_DNA.
DR AlphaFoldDB; Q9UVG5; -.
DR STRING; 559304.Q9UVG5; -.
DR EnsemblFungi; CCE72871; CCE72871; GNLVRS01_PISO0A10120g.
DR EnsemblFungi; CCE73432; CCE73432; GNLVRS01_PISO0B10187g.
DR eggNOG; ENOG502QPMM; Eukaryota.
DR HOGENOM; CLU_007078_1_0_1; -.
DR InParanoid; Q9UVG5; -.
DR OMA; FVYFPGT; -.
DR Proteomes; UP000005222; Chromosome A.
DR Proteomes; UP000005222; Chromosome B.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR010619; ThrE.
DR InterPro; IPR024528; ThrE_2.
DR Pfam; PF06738; ThrE; 1.
DR Pfam; PF12821; ThrE_2; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..995
FT /note="Pheromone-regulated membrane protein 10"
FT /id="PRO_0000409255"
FT TRANSMEM 678..698
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 700..720
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 726..746
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 752..772
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 794..814
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 833..850
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 858..878
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 881..901
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 906..926
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 965..985
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 108550 MW; 752279D556BF254A CRC64;
MSSHKGDGND SMSSDEDANE FRSHIQLPRV DLANYRKQHQ RGSSKTNIAK AGKKLKGKSV
RFPDSYGPRD TILSNSSTTN NSTESSGSSD EECDDPDSRL PSFKFNATDV KGESGDAHEG
SDGSSDGGSD DESRGSIKFS DSNDDSDRED ERRSRTSRGS VGSSSSKPLK GSDDVNEKET
NLDHDYDPQE GGTDITDQWK RTQSVSSSSK SFDGEKHSGI KGIFRKFSLA DHHGAHGFSN
DYEEPSNSDT FLGRVLSFGS GGGGGGGLIP GASRRSREKE GDEEKEVGGG GEDDGAVEMK
RLDFSQLNNE AKKLIAVHVP EAANMDQSFT YDEPNQSAGS SRNSTAPLIN PDNAQEADDD
HKHTDDEDQG KHGFYAPNLD YIIRGNDDPE DQHLLLDESG EDGYIAPPKQ VHAGVLSSLL
KLYQNPQDEK SSASLSSRAP SDGKTLAEEQ EFGTDMPYHM PTSSLDFTKL KSGPQKLVNK
FTHRSNKPQP GKEAEADDED EDEENPDQAY EKANLPSFQN ARPKAPKKTI DPVNVSSKFH
KKMKRKKIQQ QKLRITVHIS DILQRQRFIM MICKALMLYG APTHRLEEYM TMTSRVLEID
GQFVYFPGCM IVSFGDAATR TSEVHIVRCN QGVNLSKLSD THTIYKAVIH DLISVDEASQ
QLETLVRKKN QYSPWLSVFL YGFGSAMVCP FAFGGGWLDI PVTFGVGLCV GYLQFFVSSM
SNLYSSVFEI TASIVVSFIA RGIGSINNSK TFCFSAIAQG SLALILPGYI ILCGSLELQS
RNIVAGSVRM FYAIIYSLFL GFGITLGAAL FGWVYKNSTS DKKCRTSHNV NDKYRILFVP
MFTICLGLIN QARWRQLPVM MVISCTGYVG TYFAGKHFSN VPEFTAAIGA FIVGILGNVY
SRVWKGMAVS AMLPAIFVQV PSGIASQSSL LSGIQSADQI THSNSSSDSS SSDSSSSLSF
GSTMVEVSIG ISVGLFAAAL VVYPFGKRRT GLFTL
