PRM10_YEAST
ID PRM10_YEAST Reviewed; 383 AA.
AC P42946; D6VW76; E9P8R0; E9P8T9;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Pheromone-regulated membrane protein 10;
GN Name=PRM10; OrderedLocusNames=YJL108C; ORFNames=J0811;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=7483851; DOI=10.1002/yea.320110909;
RA Rasmussen S.W.;
RT "A 37.5 kb region of yeast chromosome X includes the SME1, MEF2, GSH1 and
RT CSD3 genes, a TCP-1-related gene, an open reading frame similar to the
RT DAL80 gene, and a tRNA(Arg).";
RL Yeast 11:873-883(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25, AND CONFIRMATION OF FRAMESHIFT.
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA Gates K., Gaffney T.D., Philippsen P.;
RT "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT comparison to the genome of a related fungus: Ashbya gossypii.";
RL Genome Biol. 4:R45.1-R45.13(2003).
RN [6]
RP CONFIRMATION OF FRAMESHIFT.
RC STRAIN=ATCC 204508 / S288c, and ATCC 28383 / FL100 / VTT C-80102;
RX PubMed=11054818;
RX DOI=10.1002/1097-0061(200011)16:15<1377::aid-yea637>3.0.co;2-0;
RA Sychrova H., Braun V., Potier S., Souciet J.L.;
RT "Organization of specific genomic regions of Zygosaccharomyces rouxii and
RT Pichia sorbitophila: comparison with Saccharomyces cerevisiae.";
RL Yeast 16:1377-1385(2000).
RN [7]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ThrE exporter (TC 2.A.79) family.
CC {ECO:0000305}.
CC -!- CAUTION: This is a truncated version of a ThrE family protein. Strain
CC S288c has a frameshift in position 382, which disrupts the gene coding
CC for this protein and produces two ORFs YJL107C and YJL108C. A
CC contiguous sequence for a S.cerevisiae ThrE family protein can be found
CC in strain YJM789 (AC A6ZQL9). {ECO:0000305}.
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DR EMBL; X85021; CAA59386.1; -; Genomic_DNA.
DR EMBL; Z49383; CAA89402.1; -; Genomic_DNA.
DR EMBL; AY557884; AAS56210.1; -; Genomic_DNA.
DR EMBL; AY227895; AAQ17204.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08692.1; -; Genomic_DNA.
DR PIR; S53379; S53379.
DR RefSeq; NP_012427.1; NM_001181541.1.
DR AlphaFoldDB; P42946; -.
DR BioGRID; 33648; 58.
DR DIP; DIP-7510N; -.
DR IntAct; P42946; 2.
DR MINT; P42946; -.
DR STRING; 4932.YJL108C; -.
DR PaxDb; P42946; -.
DR EnsemblFungi; YJL108C_mRNA; YJL108C; YJL108C.
DR GeneID; 853336; -.
DR KEGG; sce:YJL108C; -.
DR SGD; S000003644; PRM10.
DR VEuPathDB; FungiDB:YJL108C; -.
DR eggNOG; ENOG502QPMM; Eukaryota.
DR GeneTree; ENSGT00940000176490; -.
DR HOGENOM; CLU_007078_4_3_1; -.
DR InParanoid; P42946; -.
DR OMA; TIFMGVC; -.
DR BioCyc; YEAST:G3O-31562-MON; -.
DR PRO; PR:P42946; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P42946; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; ISM:SGD.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR010619; ThrE.
DR InterPro; IPR024528; ThrE_2.
DR Pfam; PF06738; ThrE; 1.
DR Pfam; PF12821; ThrE_2; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..383
FT /note="Pheromone-regulated membrane protein 10"
FT /id="PRO_0000203045"
FT TOPO_DOM 1..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..141
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..180
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..352
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 374..383
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 129
FT /note="F -> S (in Ref. 4; AAS56210)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 383 AA; 41488 MW; 2030F73D1823CE04 CRC64;
MIVSFGDATT RTSEVQLVRC TQGLNLWKLH QVHAVYKRVV HDTLGADEGN ALLDQILADT
NLYPPWMCVL LYAFCSAMVT PYAFGGDWVN LAISFFMGLC VGSLQFILSQ KSYMYSNVFE
ISASIVVSFC GRAFGSIPRS HICFGAVTQG SLALILPGYI ILCGALELQS RSLVAGAVRM
FYAIIYSLFL GFGITLGSAL FGWMYHNATN EISCPQLISP WFRFLFVPAF TISISLLNQA
HISQLPVMVF ISCTGYVVTY WAGKHFANST EFTAALAAFV IGVLGNLYSR IWKGLAVSAM
LPAIFVQVPS GIASQNSLLS GLQSANTIVN ANETITTSTS DPSSSMSFGM TMIQVCVGIS
VGLFASSLFV YPFGKKKTGL FSL
