ID   ATG17_ASHGO             Reviewed;         413 AA.
AC   Q757A7;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Autophagy-related protein 17;
GN   Name=ATG17; OrderedLocusNames=AER106C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Autophagy-specific protein that functions in response to
CC       autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC       to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC       timing and magnitude of the autophagy response, such as the size of the
CC       sequestering vesicles. Plays particularly a role in pexophagy and
CC       nucleophagy (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52790.1; -; Genomic_DNA.
DR   RefSeq; NP_984966.1; NM_210320.1.
DR   AlphaFoldDB; Q757A7; -.
DR   SMR; Q757A7; -.
DR   STRING; 33169.AAS52790; -.
DR   PRIDE; Q757A7; -.
DR   EnsemblFungi; AAS52790; AAS52790; AGOS_AER106C.
DR   GeneID; 4621171; -.
DR   KEGG; ago:AGOS_AER106C; -.
DR   eggNOG; ENOG502QQDW; Eukaryota.
DR   HOGENOM; CLU_051526_0_0_1; -.
DR   InParanoid; Q757A7; -.
DR   OMA; YLPENIW; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IBA:GO_Central.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0120095; C:vacuole-isolation membrane contact site; IEA:EnsemblFungi.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IEA:EnsemblFungi.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0030242; P:autophagy of peroxisome; IBA:GO_Central.
DR   GO; GO:0044805; P:late nucleophagy; IBA:GO_Central.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR   GO; GO:2000786; P:positive regulation of autophagosome assembly; IEA:EnsemblFungi.
DR   GO; GO:0045772; P:positive regulation of autophagosome size; IEA:EnsemblFungi.
DR   GO; GO:0034497; P:protein localization to phagophore assembly site; IEA:EnsemblFungi.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..413
FT                   /note="Autophagy-related protein 17"
FT                   /id="PRO_0000124555"
FT   COILED          262..300
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   413 AA;  47998 MW;  7F94482AA8877A39 CRC64;
     MSSSNQVKGF YFNAQRRLSR AQALCQNSQD TLHNMQLLLV RWQRTVSKLQ FTIHCICNQT
     VFLAECILKK TVGQQLIETE WKRMLLDELQ GEMQRSQEEI TGKIDALRRT KNELDGSGAT
     LADFISMENI FLLGDKLKDV PVVQEQVEHI KVQYESLVDK VVEQLQNNRV RKLEADFAAA
     FRSGKNDFNA FSMKYLQKIR QLETDLADIL KSLTDHYDKC SLLKAGDLPA AEQAELFEVV
     KNDDQELDSI MGVLEVIVRD IKSLAKNVSI RLRQKERDKQ QLKNAMGKAH SELLKYEEHL
     TVFQGIDDLI RNFKASCLHN VSKVRELCEF YDNFLNSYQV LLREVERRRR VAKQMEDILQ
     ACEGQLMALS DTDLKQRQQF LMRHGDYLPE NIWPGNIDDL SPLYDLEYRI KKV