PRM1_CRYNB
ID PRM1_CRYNB Reviewed; 1076 AA.
AC P0CQ05; Q55QH3; Q5KFP3;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 30.
DE RecName: Full=Plasma membrane fusion protein PRM1;
GN Name=PRM1; OrderedLocusNames=CNBF3640;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in cell fusion during mating by stabilizing the
CC plasma membrane fusion event. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PRM1 family. {ECO:0000305}.
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DR EMBL; AAEY01000032; EAL20038.1; -; Genomic_DNA.
DR RefSeq; XP_774685.1; XM_769592.1.
DR AlphaFoldDB; P0CQ05; -.
DR EnsemblFungi; EAL20038; EAL20038; CNBF3640.
DR GeneID; 4936916; -.
DR KEGG; cnb:CNBF3640; -.
DR VEuPathDB; FungiDB:CNBF3640; -.
DR HOGENOM; CLU_320542_0_0_1; -.
DR Proteomes; UP000001435; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043332; C:mating projection tip; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR026777; PRM1.
DR PANTHER; PTHR31030; PTHR31030; 1.
PE 3: Inferred from homology;
KW Cell membrane; Conjugation; Glycoprotein; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1076
FT /note="Plasma membrane fusion protein PRM1"
FT /id="PRO_0000410212"
FT TOPO_DOM 1..66
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..350
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 372..432
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 433..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 456..646
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 647..667
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 668..1076
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1009
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 235
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 266
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 306
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 476
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 496
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 526
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 533
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 548
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 602
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1076 AA; 117377 MW; 0A47AC8AB2150418 CRC64;
MSYPQAPSKF VNPDEIIPLS PPTKPPFAQY AASPLPATPH TPYSPPSPSR LSETIPLRPY
LSLLPRILLT FFSPCLLPMI LTIAHLIQNR SSTASLATSL KSSVLSACSG LAKGAASIKT
LPRYLAMQTN QEAIRATQAS ILAIGTMLMD AITIIEVVVN FIVDTYRSLL LCTIELAVRG
TLEILISAVQ TISDAVTDTL NSVRSNIQDD IGDANDIIQT AVSAINRVTT LVNLNISVPE
FSIPALSFLQ NVTIPTTFED GLITLNSSLP TLTDLKKKMD EIIDTPFEAL ISEINSTRLE
MAASFNSSIL SVPSLSSLSA NSAKDLSNDL CSDLDTSLID DTAKALHKLS SIAIGLMFLL
LFLIWAALAV WEWRKWKLMK DTVDAVNEEW DRDGKSDAWR MVAIVEHPVL ERYSGTFLGK
IAKMPRTRTN LRWFLSYLAH PTCLALLFIS LFGFLSIQFQ LVALNALKAH AQSSANSTVT
ASTNSLVTKL NAAALNSSQE YADSYNEAIA GYQDRINNEL FGSWVNTTAI TLNSTLVEFY
DEVEKALNAS FGGTILYNPI NTFMYCILGS KITNLEKGLT WISEHAFVDL PTFPSDILLL
SNDSMNEIAT PIAAAAVGSG DGGDDDDGVV GTLISHFESA LKVERTFYGI MLGVWLALFL
IGLAVVIWNS GGRENFMALR GVPSSSSPPG YGPPESKHPR WKAWLTNNHP IYDSYAEKQF
RGTTPTNCLE SYTHADVPNV NNGNDDHEKS FFKMRDSHAA GPFGSHATSA VRSTIASLAA
PGQSFLKLSG RKLTDTTTPY DDKVPLAPVQ TSEKYSRDHA NSPFPRPSSE SSESSAAQPF
WVDKFYGAFE GVKSFFPTRS QRLGAALARK ASQRTEGSFG ASQVPTARTP GHDWIGGHQC
PPEKKAEPEW SMVDPRMLGR ALEDDKGRYP RVLPPSEMAA ANYNPHPVYP RPMSRAPTLG
EGMVIPSTTS HPDPFQDMPP LPPKHKRASM DYVEEYESSH SRSSREDSRH GGVTSPASSS
VSYFAAEPQL VSASKVQVGV AQKGGQATRA LAEIVKELQE KRERKDPFGD DYERGL
