PRM1_CRYNJ
ID PRM1_CRYNJ Reviewed; 1076 AA.
AC P0CQ04; Q55QH3; Q5KFP3;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=Plasma membrane fusion protein PRM1;
GN Name=PRM1; OrderedLocusNames=CNF01070;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in cell fusion during mating by stabilizing the
CC plasma membrane fusion event. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PRM1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAW44262.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AE017346; AAW44262.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_571569.1; XM_571569.1.
DR AlphaFoldDB; P0CQ04; -.
DR STRING; 5207.AAW44262; -.
DR EnsemblFungi; AAW44262; AAW44262; CNF01070.
DR GeneID; 3258038; -.
DR VEuPathDB; FungiDB:CNF01070; -.
DR eggNOG; ENOG502QRP5; Eukaryota.
DR InParanoid; P0CQ04; -.
DR OrthoDB; 306736at2759; -.
DR Proteomes; UP000002149; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043332; C:mating projection tip; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032220; P:plasma membrane fusion involved in cytogamy; IBA:GO_Central.
DR InterPro; IPR026777; PRM1.
DR PANTHER; PTHR31030; PTHR31030; 1.
PE 3: Inferred from homology;
KW Cell membrane; Conjugation; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1076
FT /note="Plasma membrane fusion protein PRM1"
FT /id="PRO_0000337279"
FT TOPO_DOM 1..66
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..350
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 372..432
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 433..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 456..646
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 647..667
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 668..1076
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1009
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 235
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 266
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 306
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 476
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 496
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 526
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 533
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 548
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 602
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1076 AA; 117355 MW; 8EA83F133888336E CRC64;
MSYPQAPSKF VNPDEIIPLS PPTKPPFAQY AASPLPATPH TPYSPPSPSR LSETIPLRPY
LSLLPRILLT FFSPCLLPMI LTIAHLIQNR SSTASLATSL KSSVLSACSG LAKAAASIKT
LPRYLAMQTN QEAIRATQAS ILAIGTMLMD AITIIEAVVN FIVDTYRSLL LCTIELAVRG
TLEILISAVQ TISDAVTDTL NSVRSNIQDD IGDANDIIQT AVSAINRVTT LVNLNISVPE
FSIPALSFLQ NVTIPTTFED GLITLNSSLP TLTDLKKKMD EIIDTPFEAL ISEINSTRLE
MAASFNSSIL SVPSLSSLSA NSANDLSNDL CSDLDTSLID DTAKALHKLS SIAIGLMFLL
LFLIWAALAV WEWRKWKLMK DTVDAVNEEW DRDGKSDAWR MVAIVEHPVL ERYSGTFLGK
IAKMPRTRTN LRWFLSYLAH PTCLALLFIS LFGFLSIQFQ LVALNALKAH AQSSANSTVT
ASTNSLVTKL NAAALNSSQE YADSYNEAIA GYQDRINNEL FGSWVNTTAV TLNSTLVEFY
DEVEKALNAS FGGTILYNPI NTFMYCILGS KITNLEKGLT WISEHAFVDL PTFPSDILLL
SNDSMNEIAT PIAAAAVGSG DGGDDDDGVV GTLISHFESA LKVERTFYGI MLGVWLALFL
IGLAVVIWNS GGREKFMALR GVPSSSSPPG YGPPESKHPR WKAWLTNNHP IYDSYAEKQF
RGTTPTNCLE SYTHADVPNV NNGNDDHEKS FFKMRDSHAA GPFGSHATSA VRSTIASLAA
PGQSFLKLSG RKLTDTTTPY DDKVPLAPVQ TSEKYSRDHA NSPFPRPSSE SSESSAAQPF
WVDKFYGAFE GVKSFFPTRS QRLGAALARK ASQRTEGSFG ASQVPTARTP GHDWIGGHQC
LPEKKAEPEW SMVDPRMLGR ALEDDKGRYP RVLPPSEMAA ANYNPHPVYP RPMSRASTLG
EGMVIPSTTS HPDPFQDMPP LPPKHKRASM DYVEEYESSH SRSSREDSRH GGVTSPASSS
VSYFAAEPQL VSASKVQVGV AQKGGQATRA LAEIVKELQE KRERKDPFGD DYERGL
