ID   ATG17_ASPFU             Reviewed;         551 AA.
AC   Q4X0B0;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Autophagy-related protein 17;
GN   Name=atg17; ORFNames=AFUA_2G14100;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Autophagy-specific protein that functions in response to
CC       autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC       to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC       timing and magnitude of the autophagy response, such as the size of the
CC       sequestering vesicles. Plays particularly a role in pexophagy and
CC       nucleophagy (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; AAHF01000001; EAL93705.1; -; Genomic_DNA.
DR   RefSeq; XP_755743.1; XM_750650.1.
DR   AlphaFoldDB; Q4X0B0; -.
DR   SMR; Q4X0B0; -.
DR   STRING; 746128.CADAFUBP00002911; -.
DR   EnsemblFungi; EAL93705; EAL93705; AFUA_2G14100.
DR   GeneID; 3513148; -.
DR   KEGG; afm:AFUA_2G14100; -.
DR   VEuPathDB; FungiDB:Afu2g14100; -.
DR   eggNOG; ENOG502RYHP; Eukaryota.
DR   HOGENOM; CLU_028356_0_0_1; -.
DR   InParanoid; Q4X0B0; -.
DR   OMA; SSINHVW; -.
DR   OrthoDB; 1496047at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IBA:GO_Central.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0030242; P:autophagy of peroxisome; IBA:GO_Central.
DR   GO; GO:0044805; P:late nucleophagy; IBA:GO_Central.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..551
FT                   /note="Autophagy-related protein 17"
FT                   /id="PRO_0000124556"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          502..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   551 AA;  60950 MW;  2FF58BAF901C3FDF CRC64;
     MSSSESSSVS GGGRPDAGRL PGEEQAMPRL DTLISHLVAA KRSLSSINHV WRANEIVTAA
     RAALEECVVV SARTAFLRRG LNNQLRLLYS VRTEVEEISL RGRSEFAAVL KDLDDADTRL
     RRTLELLRET IVHPAFRPEG EDPKSLHDFV DERGVEELHA ALKSSIDRTT AAQAQLDSSN
     HAFDDELLSI KEALGTYRTA AKLASSRSSS SASSSSTSNS SLPSISTMPS MLHSLEMHAQ
     EMANLLESLV RHFDLCVTAV KHTEGGGAAA KSITGDMPVG VPVSGRMGSN IEEEINNNLN
     APLDPLSNSE YQEMVNVLFK DAAEAEDVVM EIQDRIGEME SVLENVLAQR DALRSIYNAT
     TDIYQHLSSL GSTRLPGYIA QAHNFTQVWH EENDRISGGL ADLSDLNSLY NGFLDAYDGL
     IVEVARRKHV RQRVEKVLRD TRHKLDQLYE EDVTARETFR VEKGDYLPSD IWPEIGREPM
     RIEFRRISGA KVQAVNLQSP NEQEAITDEQ KTANRLAPVE SKDGDEIIPD LPRELVEQAF
     ARLKARAKDA T