ID   PRM2_HORSE              Reviewed;          62 AA.
AC   P15342;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Sperm histone P2a;
DE   AltName: Full=Protamine 2a;
DE   AltName: Full=ST2a;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2364093; DOI=10.1016/0167-4838(90)90183-g;
RA   Pirhonen A., Valtonen P., Linnala-Kankkunen A., Heiskanen M.-L.,
RA   Maenpaa P.K.;
RT   "Primary structures of two protamine 2 variants (St2a and St2b) from
RT   stallion spermatozoa.";
RL   Biochim. Biophys. Acta 1039:177-180(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-25.
RX   PubMed=2924903; DOI=10.1016/0014-5793(89)81192-5;
RA   Pirhonen A., Linnala-Kankkunen A., Maenpaa P.K.;
RT   "Comparison of partial amino acid sequences of two protamine 2 variants
RT   from stallion sperm. Structural evidence that the variants are products of
RT   different genes.";
RL   FEBS Lett. 244:199-202(1989).
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex.
CC       {ECO:0000250|UniProtKB:P07978}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P07978}.
CC       Chromosome {ECO:0000250|UniProtKB:P07978}.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- PTM: Proteolytic processing into mature chains is required for histone
CC       eviction during spermatogenesis. Transition proteins (TNP1 and TNP2)
CC       are required for processing. {ECO:0000250|UniProtKB:P07978}.
CC   -!- SIMILARITY: Belongs to the protamine P2 family. {ECO:0000305}.
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DR   PIR; S10754; S10754.
DR   AlphaFoldDB; P15342; -.
DR   PRIDE; P15342; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
PE   1: Evidence at protein level;
KW   Chromosome; Developmental protein; Differentiation;
KW   Direct protein sequencing; DNA condensation; DNA-binding; Nucleosome core;
KW   Nucleus; Reference proteome; Spermatogenesis.
FT   CHAIN           1..62
FT                   /note="Sperm histone P2a"
FT                   /id="PRO_0000191596"
SQ   SEQUENCE   62 AA;  8418 MW;  15EABC109F2AD6B1 CRC64;
     ARTTAGSYRR YRRRCCSPRR LYRLRRRRYR SSRRRRRRPC RRRRHRRVCR RVRRRRRCCR
     RR