PRM2_PANTR
ID PRM2_PANTR Reviewed; 102 AA.
AC P35300; Q71TU7;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Protamine-2;
DE AltName: Full=Sperm histone P2;
DE AltName: Full=Sperm protamine P2;
GN Name=PRM2;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8513810; DOI=10.1111/j.1432-1033.1993.tb17960.x;
RA Retief J.D., Dixon G.H.;
RT "Evolution of pro-protamine P2 genes in primates.";
RL Eur. J. Biochem. 214:609-615(1993).
RN [2]
RP ERRATUM OF PUBMED:8513810.
RX PubMed=8281927;
RA Retief J.D., Dixon G.H.;
RL Eur. J. Biochem. 218:1095-1095(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10659848; DOI=10.1038/35002070;
RA Wyckoff G.J., Wang W., Wu C.-I.;
RT "Rapid evolution of male reproductive genes in the descent of man.";
RL Nature 403:304-309(2000).
CC -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC during the haploid phase of spermatogenesis. They compact sperm DNA
CC into a highly condensed, stable and inactive complex.
CC {ECO:0000250|UniProtKB:P07978}.
CC -!- SUBUNIT: Interacts with TDRP. {ECO:0000250|UniProtKB:P07978}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P07978}.
CC Chromosome {ECO:0000250|UniProtKB:P07978}.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- PTM: Proteolytic processing into mature chains is required for histone
CC eviction during spermatogenesis. Transition proteins (TNP1 and TNP2)
CC are required for processing. {ECO:0000250|UniProtKB:P07978}.
CC -!- SIMILARITY: Belongs to the protamine P2 family. {ECO:0000305}.
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DR EMBL; X72968; CAA51474.1; -; Genomic_DNA.
DR EMBL; AF215711; AAF34630.1; -; Genomic_DNA.
DR PIR; S33331; S33331.
DR RefSeq; NP_001009084.1; NM_001009084.1.
DR AlphaFoldDB; P35300; -.
DR STRING; 9598.ENSPTRP00000013259; -.
DR PaxDb; P35300; -.
DR GeneID; 453921; -.
DR KEGG; ptr:453921; -.
DR CTD; 5620; -.
DR eggNOG; ENOG502TD5P; Eukaryota.
DR InParanoid; P35300; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0006997; P:nucleus organization; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR InterPro; IPR000492; PRM2.
DR PANTHER; PTHR21341; PTHR21341; 1.
DR Pfam; PF00841; Protamine_P2; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Developmental protein; Differentiation; DNA condensation;
KW DNA-binding; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome;
KW Spermatogenesis.
FT CHAIN 1..102
FT /note="Protamine-2"
FT /id="PRO_0000191605"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P11248"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P11248"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P11248"
SQ SEQUENCE 102 AA; 12976 MW; 96EC78ABB8CF64DB CRC64;
MVRYRVRSPS EPSHEVYRQQ LHGQEQGHHG QEEQGLSPEH VEVYERTHGH SHYRRRHCSR
RRLRRIHRQQ HRSCRRRKRR SCRHRRKHRR GCRTRRRTCR RH
