ID   PRM2_YEAST              Reviewed;         656 AA.
AC   P40534; D6VVP5;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Pheromone-regulated membrane protein 2;
GN   Name=PRM2; OrderedLocusNames=YIL037C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169870;
RA   Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA   Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA   Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA   Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA   Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL   Nature 387:84-87(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NOMENCLATURE, AND INDUCTION.
RX   PubMed=11062271; DOI=10.1083/jcb.151.3.719;
RA   Heiman M.G., Walter P.;
RT   "Prm1p, a pheromone-regulated multispanning membrane protein, facilitates
RT   plasma membrane fusion during yeast mating.";
RL   J. Cell Biol. 151:719-730(2000).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: By pheromone. {ECO:0000269|PubMed:11062271}.
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DR   EMBL; Z46861; CAA86914.1; -; Genomic_DNA.
DR   EMBL; BK006942; DAA08511.1; -; Genomic_DNA.
DR   PIR; S49941; S49941.
DR   RefSeq; NP_012227.3; NM_001179387.3.
DR   AlphaFoldDB; P40534; -.
DR   SMR; P40534; -.
DR   BioGRID; 34953; 110.
DR   DIP; DIP-6544N; -.
DR   IntAct; P40534; 1.
DR   STRING; 4932.YIL037C; -.
DR   iPTMnet; P40534; -.
DR   PaxDb; P40534; -.
DR   PRIDE; P40534; -.
DR   EnsemblFungi; YIL037C_mRNA; YIL037C; YIL037C.
DR   GeneID; 854774; -.
DR   KEGG; sce:YIL037C; -.
DR   SGD; S000001299; PRM2.
DR   VEuPathDB; FungiDB:YIL037C; -.
DR   eggNOG; ENOG502S7IH; Eukaryota.
DR   HOGENOM; CLU_448477_0_0_1; -.
DR   InParanoid; P40534; -.
DR   OMA; DHINTAR; -.
DR   BioCyc; YEAST:G3O-31309-MON; -.
DR   PRO; PR:P40534; -.
DR   Proteomes; UP000002311; Chromosome IX.
DR   RNAct; P40534; protein.
DR   GO; GO:0016021; C:integral component of membrane; ISM:SGD.
DR   GO; GO:0000742; P:karyogamy involved in conjugation with cellular fusion; IMP:SGD.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..656
FT                   /note="Pheromone-regulated membrane protein 2"
FT                   /id="PRO_0000202994"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        634..654
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   656 AA;  75021 MW;  63787C6982065607 CRC64;
     MNNVHIIKPL SLPQRFFSCI FHPLLLIFFT SVILTIWGSF SVIDITMAKM SHAQVKRNDT
     VSTFASISTA TATATTTATT TATMTAVTTQ HAIYSANSYS LNKTFIDNTI DQYFESKLRS
     IESTVGTDMQ EKFKSYTDDI LDNKQKLIND QISLETELIK EVLEVNNTIF NELLTKSQLI
     NDTWNEISED AMTIDKDSIS QMASNLLLNY SMFDSIFGNY SRKLKSLQNF NGTITDFSTQ
     LDTSSTLSLN FLRNSTDWLQ LKRNFTANLQ NEISILSGGS TEVTSSTSII KRSLKTNSEE
     NSVLSAVKNH VFRKCKRMTI IFTVMYFAFV ILLMAIERIL FQLENQQVNL VMSQINGLTG
     QTNFTKYNKV LKSLITTLNL STLYPIPYQL TKLINQKIFK REPEKIDDKK VKKSKLFYCN
     WWIISNGAHL WLFGFLMLLI HWQIVTRLTN FEVPSLPTFH KRAGPSLYKR EVWTDGNITT
     TIEGFINDSV SLLCENFQME VNEKFITANL SLQTDPNLKV QSTDILNLWV NDTNTQFEKY
     LNESSQNWQG IDLQVEPLLG SDSINEFLGQ YFLPTYEVTN TNSSFALDIQ KYGIINRGIN
     ITNASVAALS SLSKRQIKDK EQKQTYFLHT VYKWGLLAVC LTILFHHMLI FIILKL