ID   PRM3_HUMAN              Reviewed;         103 AA.
AC   Q9NNZ6;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Protamine-3;
DE   AltName: Full=Sperm protamine P3;
GN   Name=PRM3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8720108;
RX   DOI=10.1002/(sici)1098-2795(199601)43:1<1::aid-mrd1>3.0.co;2-w;
RA   Schlueter G., Celik A.B., Obata R., Schlicker M., Hofferbert S.,
RA   Schlung A., Adham I.M., Engel W.;
RT   "Sequence analysis of the conserved protamine gene cluster shows that it
RT   contains a fourth expressed gene.";
RL   Mol. Reprod. Dev. 43:1-6(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protamine P3 family. {ECO:0000305}.
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DR   EMBL; Z46940; CAB92526.1; -; Genomic_DNA.
DR   EMBL; KF459690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC009121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS76821.1; -.
DR   AlphaFoldDB; Q9NNZ6; -.
DR   STRING; 9606.ENSP00000325638; -.
DR   PhosphoSitePlus; Q9NNZ6; -.
DR   BioMuta; PRM3; -.
DR   DMDM; 74734290; -.
DR   MassIVE; Q9NNZ6; -.
DR   PaxDb; Q9NNZ6; -.
DR   PeptideAtlas; Q9NNZ6; -.
DR   PRIDE; Q9NNZ6; -.
DR   ProteomicsDB; 81879; -.
DR   DNASU; 58531; -.
DR   Ensembl; ENST00000327157.4; ENSP00000325638.2; ENSG00000178257.4.
DR   MANE-Select; ENST00000327157.4; ENSP00000325638.2; NM_021247.3; NP_067070.2.
DR   UCSC; uc002dat.3; human.
DR   GeneCards; PRM3; -.
DR   HGNC; HGNC:13732; PRM3.
DR   HPA; ENSG00000178257; Tissue enriched (testis).
DR   neXtProt; NX_Q9NNZ6; -.
DR   OpenTargets; ENSG00000178257; -.
DR   PharmGKB; PA33794; -.
DR   VEuPathDB; HostDB:ENSG00000178257; -.
DR   eggNOG; ENOG502T3TU; Eukaryota.
DR   GeneTree; ENSGT00390000001558; -.
DR   HOGENOM; CLU_2398985_0_0_1; -.
DR   InParanoid; Q9NNZ6; -.
DR   OrthoDB; 1628050at2759; -.
DR   PhylomeDB; Q9NNZ6; -.
DR   PathwayCommons; Q9NNZ6; -.
DR   SignaLink; Q9NNZ6; -.
DR   Pharos; Q9NNZ6; Tdark.
DR   PRO; PR:Q9NNZ6; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q9NNZ6; protein.
DR   Bgee; ENSG00000178257; Expressed in left testis and 82 other tissues.
DR   Genevisible; Q9NNZ6; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0030317; P:flagellated sperm motility; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR026077; PRMP3.
DR   PANTHER; PTHR14317; PTHR14317; 1.
PE   3: Inferred from homology;
KW   Chromosome; Developmental protein; Differentiation; DNA condensation;
KW   DNA-binding; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome;
KW   Spermatogenesis.
FT   CHAIN           1..103
FT                   /note="Protamine-3"
FT                   /id="PRO_0000261158"
FT   REGION          1..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..65
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..94
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         95
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q64256"
FT   VARIANT         100
FT                   /note="R -> Q (in dbSNP:rs429744)"
FT                   /id="VAR_034414"
FT   CONFLICT        86
FT                   /note="H -> Q (in Ref. 1; CAB92526)"
SQ   SEQUENCE   103 AA;  11269 MW;  DB72EF8217258601 CRC64;
     MGSRCAKLNT GQSPGHSPGH STGHGRGHES SMKKLMACVS QDNFSLSSAG EEEEEEEEEG
     EEEEKEELPV QGKLLLLEPE RQEEGHKDNA EAQQSPEPKR TPS