PRM4_YEAST
ID PRM4_YEAST Reviewed; 284 AA.
AC Q12498; D6W3L2;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Pheromone-regulated membrane protein 4;
GN Name=PRM4; OrderedLocusNames=YPL156C; ORFNames=P2578;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=8948103;
RX DOI=10.1002/(sici)1097-0061(199611)12:14<1483::aid-yea34>3.0.co;2-o;
RA Purnelle B., Coster F., Goffeau A.;
RT "The sequence of 55 kb on the left arm of yeast chromosome XVI identifies a
RT small nuclear RNA, a new putative protein kinase and two new putative
RT regulators.";
RL Yeast 12:1483-1492(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP PROTEIN SEQUENCE OF 158-165; 220-246 AND 259-266, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RA Bienvenut W.V., Peters C.;
RL Submitted (JUN-2005) to UniProtKB.
RN [5]
RP NOMENCLATURE.
RX PubMed=11062271; DOI=10.1083/jcb.151.3.719;
RA Heiman M.G., Walter P.;
RT "Prm1p, a pheromone-regulated multispanning membrane protein, facilitates
RT plasma membrane fusion during yeast mating.";
RL J. Cell Biol. 151:719-730(2000).
CC -!- INTERACTION:
CC Q12498; P38768: PIH1; NbExp=3; IntAct=EBI-32462, EBI-24499;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X96770; CAA65565.1; -; Genomic_DNA.
DR EMBL; Z73512; CAA97861.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11278.1; -; Genomic_DNA.
DR PIR; S65167; S65167.
DR RefSeq; NP_015169.1; NM_001183970.1.
DR AlphaFoldDB; Q12498; -.
DR SMR; Q12498; -.
DR BioGRID; 36027; 82.
DR DIP; DIP-5502N; -.
DR IntAct; Q12498; 3.
DR MINT; Q12498; -.
DR STRING; 4932.YPL156C; -.
DR MaxQB; Q12498; -.
DR PaxDb; Q12498; -.
DR PRIDE; Q12498; -.
DR EnsemblFungi; YPL156C_mRNA; YPL156C; YPL156C.
DR GeneID; 855947; -.
DR KEGG; sce:YPL156C; -.
DR SGD; S000006077; PRM4.
DR VEuPathDB; FungiDB:YPL156C; -.
DR eggNOG; KOG1752; Eukaryota.
DR HOGENOM; CLU_066481_0_0_1; -.
DR InParanoid; Q12498; -.
DR OMA; DLEKHSH; -.
DR BioCyc; YEAST:G3O-34052-MON; -.
DR PRO; PR:Q12498; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q12498; protein.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; ISM:SGD.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..284
FT /note="Pheromone-regulated membrane protein 4"
FT /id="PRO_0000058579"
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 157..272
FT /note="Glutaredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00686"
SQ SEQUENCE 284 AA; 32012 MW; 335AD07562146DB7 CRC64;
MIADSSVLKK HTAIKRSTRI ISLTLVLLGV FSFLLLTWND SLEFYNSADP SENKKNSEEE
SEKKFVYKLP NLLKTADSFL SNENELNFQK VKEEISNIQS EVEVDIPEPS SKATSKFSSR
SFQTDNVVTA TTTTTLNPRS SSLALQKNCD HKKFDPRTDF LDIIRTSPAV LFIKSSQADS
IFLKNLLQRE FEISPELATV DLEKHSHGYE LEKYIKQNKL NIDTSAALES IQSPYLFLNG
ISVINRGMVR DIIEPHSKGL LLPLLKSEAR GNLLVEKKDI PSNS
