PRM7_YEAST
ID PRM7_YEAST Reviewed; 698 AA.
AC Q12459; D6VRV6; Q99175;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Pheromone-regulated protein PRM7;
GN Name=PRM7; OrderedLocusNames=YDL039C; ORFNames=D2723, D2726, YDL038C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9046088;
RX DOI=10.1002/(sici)1097-0061(199701)13:1<65::aid-yea50>3.0.co;2-t;
RA Saren A.-M., Laamanen P., Lejarcegui J.B., Paulin L.;
RT "The sequence of a 36.7 kb segment on the left arm of chromosome IV from
RT Saccharomyces cerevisiae reveals 20 non-overlapping open reading frames
RT (ORFs) including SIT4, FAD1, NAM1, RNA11, SIR2, NAT1, PRP9, ACT2 and MPS1
RT and 11 new ORFs.";
RL Yeast 13:65-71(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [3]
RP GENOME REANNOTATION, SEQUENCE REVISION, AND IDENTIFICATION OF FRAMESHIFT.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 584-698.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP NOMENCLATURE, AND INDUCTION.
RX PubMed=11062271; DOI=10.1083/jcb.151.3.719;
RA Heiman M.G., Walter P.;
RT "Prm1p, a pheromone-regulated multispanning membrane protein, facilitates
RT plasma membrane fusion during yeast mating.";
RL J. Cell Biol. 151:719-730(2000).
RN [6]
RP INDUCTION.
RX PubMed=12871953; DOI=10.1074/jbc.m303008200;
RA Santiago T.C., Mamoun C.B.;
RT "Genome expression analysis in yeast reveals novel transcriptional
RT regulation by inositol and choline and new regulatory functions for Opi1p,
RT Ino2p, and Ino4p.";
RL J. Biol. Chem. 278:38723-38730(2003).
RN [7]
RP INDUCTION.
RX PubMed=12509465; DOI=10.1128/mcb.23.2.677-686.2003;
RA Lamb T.M., Mitchell A.P.;
RT "The transcription factor Rim101p governs ion tolerance and cell
RT differentiation by direct repression of the regulatory genes NRG1 and SMP1
RT in Saccharomyces cerevisiae.";
RL Mol. Cell. Biol. 23:677-686(2003).
CC -!- INDUCTION: Induced by pheromone. Down-regulated by RIM101 and inositol.
CC {ECO:0000269|PubMed:11062271, ECO:0000269|PubMed:12509465,
CC ECO:0000269|PubMed:12871953}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA96450.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA96451.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA98597.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA98598.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; Z71781; CAA96450.1; ALT_FRAME; Genomic_DNA.
DR EMBL; Z71781; CAA96451.1; ALT_FRAME; Genomic_DNA.
DR EMBL; Z74087; CAA98597.1; ALT_FRAME; Genomic_DNA.
DR EMBL; Z74087; CAA98598.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AY557637; AAS55963.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11816.1; -; Genomic_DNA.
DR PIR; S67571; S67571.
DR PIR; S67572; S67572.
DR RefSeq; NP_010245.2; NM_001180098.1.
DR AlphaFoldDB; Q12459; -.
DR BioGRID; 32019; 115.
DR STRING; 4932.YDL039C; -.
DR PaxDb; Q12459; -.
DR EnsemblFungi; YDL039C_mRNA; YDL039C; YDL039C.
DR GeneID; 851522; -.
DR KEGG; sce:YDL039C; -.
DR SGD; S000002197; PRM7.
DR VEuPathDB; FungiDB:YDL039C; -.
DR HOGENOM; CLU_443593_0_0_1; -.
DR OMA; KPIATKY; -.
DR BioCyc; YEAST:G3O-29462-MON; -.
DR PRO; PR:Q12459; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q12459; protein.
DR GO; GO:0016021; C:integral component of membrane; ISM:SGD.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..698
FT /note="Pheromone-regulated protein PRM7"
FT /id="PRO_0000262750"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 70123 MW; EDF687608FCC5268 CRC64;
MYRTRSSDEV TTSTDLTSSS DVATSVDPTT SVISSTSADP TTSADSTTST VQTTSAGPSN
NIGNSTLANS TTFAVSSTSI DPTSSSDVIT STVQTTSIEP TTSLVSSNDI TTSTSLNISV
VISTSTDSTS LIESTTTVGP HASSSVAGMY RTRSSDEVTT STDPTSSSDV ATSADPTSSS
AVTTLVDPTT SVVISTSVDQ TSSSDVATSV DPTTSVISST SADPTTSADS TTSTVQTTSV
DPTSSVVSSA PVDPASSVVS LTSSYPTSSS TVTISANSNG SATLAAQTTS IDPVSSIVSS
SGATTIISSA SIDPASSVVS STSSEPTSFI VSSTSVYSTR PSGPTTSTDL ATFSDTIILR
VSTTSTSQDT QTVSSSLTDM VSSTGSADLS VSSIQRSQVD PSTFAVSNSP VYPTASTGST
STGIPIASES LSLSRQQGIS ATSSSSIVTL TPVDSASSSR SSATSIIKPN MPVSSNDSKT
QSSVSVVDAF QSTKSSYPSI TSADPTTLAS ENGLVGSSSS AHPITLDRTY ASAHASVTDI
VSRVTDSTRH TTLVTSNINI QSEVGNPNYS GPKDTTITKQ SAFMTSPAST STISNVQSTA
SVMNHSIEDN ISAAASLESV SGTSTKDYSS QSSAIHYTNS FTTTTTNAFI TSKHSIAAVS
TGAITSSASI SLIMEGSANI EAVGKLVWLA AALPLAFI
