ID   ATG17_CANAL             Reviewed;         476 AA.
AC   Q5AI71; A0A1D8PCV4; O94027;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Autophagy-related protein 17;
GN   Name=ATG17; OrderedLocusNames=CAALFM_C102910CA;
GN   ORFNames=Ca49C10.13, CaO19.10499, CaO19.2982;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1161;
RA   Oliver K., Harris D., Barrell B.G., Rajandream M.A.;
RT   "Candida albicans strain 1161 genome pilot sequencing project.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Autophagy-specific protein that functions in response to
CC       autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC       to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC       timing and magnitude of the autophagy response, such as the size of the
CC       sequestering vesicles. Plays particularly a role in pexophagy and
CC       nucleophagy (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; AL033497; CAA21977.1; -; Genomic_DNA.
DR   EMBL; CP017623; AOW25972.1; -; Genomic_DNA.
DR   PIR; T52157; T52157.
DR   RefSeq; XP_721480.1; XM_716387.1.
DR   AlphaFoldDB; Q5AI71; -.
DR   SMR; Q5AI71; -.
DR   STRING; 237561.Q5AI71; -.
DR   GeneID; 3636829; -.
DR   KEGG; cal:CAALFM_C102910CA; -.
DR   CGD; CAL0000200723; orf19.10499.
DR   VEuPathDB; FungiDB:C1_02910C_A; -.
DR   eggNOG; ENOG502RW77; Eukaryota.
DR   HOGENOM; CLU_565132_0_0_1; -.
DR   InParanoid; Q5AI71; -.
DR   OMA; QCMKAVE; -.
DR   OrthoDB; 1496047at2759; -.
DR   PRO; PR:Q5AI71; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IBA:GO_Central.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0030242; P:autophagy of peroxisome; IBA:GO_Central.
DR   GO; GO:0044805; P:late nucleophagy; IBA:GO_Central.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..476
FT                   /note="Autophagy-related protein 17"
FT                   /id="PRO_0000124557"
FT   CONFLICT        301
FT                   /note="K -> N (in Ref. 1; CAA21977)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   476 AA;  55407 MW;  1AA5B5176E1CCA62 CRC64;
     MTNEINSATV TQDEVIKWSR EAQSTLEKTQ KICTDAQSSM QKTAQELTIL IPDKLQAIEF
     LFKSYREQYD SILKQIETTK IYLHTNIDKV FNDIKDLLDP SLARLNNILL ELKKTRVPSI
     VVEGTSEGKT LFDFTSIQSI NLLKENIGIF KSNCSKIKNL LDLEVKEKLN IEQDRMNSRW
     NKSVKMYDLI APLQLELRAL IHGASNESNS FMGTILRENQ ALENELVSIL EMQTNHFDQC
     MKAVELISSG NGCDMNLGVL KNDAQELPEV FKELTTIYDI ILRNEERSKK FLATHMPNIE
     KISDIVKEEL AVFRKFKTEE IPRYTFLIAE CENKLKECSM PVKSDQSPSQ VYTQTLQELT
     EHYVKFINIY KTKYLAELHH QQFTYPRKFL KKLTEFLNED IYRIQIEESE RRRQWTSRYG
     EFIPSEFKLP GEHELPVIVQ IITEGLEYIQ KEDGQEEEPN IGNEKELMDM ITGSNK