ID   ATG17_DICDI             Reviewed;         488 AA.
AC   B0G140;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Probable autophagy-related protein 17;
GN   Name=atg17; ORFNames=DDB_G0295673;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Autophagy-specific protein that functions in response to
CC       autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC       to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC       timing and magnitude of the autophagy response, such as the size of the
CC       sequestering vesicles. Plays particularly a role in pexophagy and
CC       nucleophagy (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; AAFI02000046; EDR41068.1; -; Genomic_DNA.
DR   RefSeq; XP_001733002.1; XM_001732950.1.
DR   AlphaFoldDB; B0G140; -.
DR   SMR; B0G140; -.
DR   STRING; 44689.DDB0237867; -.
DR   PaxDb; B0G140; -.
DR   EnsemblProtists; EDR41068; EDR41068; DDB_G0295673.
DR   GeneID; 8623455; -.
DR   KEGG; ddi:DDB_G0295673; -.
DR   dictyBase; DDB_G0295673; atg17.
DR   eggNOG; ENOG502RW78; Eukaryota.
DR   HOGENOM; CLU_559506_0_0_1; -.
DR   InParanoid; B0G140; -.
DR   OMA; QCDFITF; -.
DR   PRO; PR:B0G140; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IBA:GO_Central.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0030242; P:autophagy of peroxisome; IBA:GO_Central.
DR   GO; GO:0044805; P:late nucleophagy; IBA:GO_Central.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..488
FT                   /note="Probable autophagy-related protein 17"
FT                   /id="PRO_0000367254"
FT   REGION          103..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          257..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..284
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  57014 MW;  7C6211B043B1BEB2 CRC64;
     MDFSSKSLEL CKSHSNQTDQ LLKISKQTYE KYDNSLSKLH LIIRELNKQL IILKETSTQF
     NDRYNTFIND FTSLSNQKQS LFTSIENKLE ILKKKYLDKG LVFKNNNNNN NNNNNNNNNN
     NNNSNKSTED DNNENNNNND VNKNNNNNNN NNLNTLYDFI DIESLELIKN QFLSELSGLN
     EICDKSKQIY KSTNESNLEM ENRFLEIQKQ YNKQIEESNS LSDLLTQQNN LYKTIQNQLI
     NVASQCDFIT FYKPSPSPLS PSPSPSSSSS SSSPSPSSPQ QQHDFNINNK KEQIQLLLTS
     SLENIQLMSK NVKDIENQFK ESCSIYTLVY LLNEKLSFGN DFSENWETFE RFNCIFEQRL
     AGANYFIGEL YSLGKWYDLF DESYDNLLEE VKRRQKEYLR QKTIAEQFNE ELKHNYNQEI
     QNRLKFYDSY GKYLPVSLFS TISDQPISFQ VKQIIEESVI DYSFNPLNLK RSSPINQQQQ
     QQQPPPNS