ATG17_GIBZE
ID ATG17_GIBZE Reviewed; 519 AA.
AC I1RR07; A0A098DWM6; A0A1C3YKK3;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 1.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=Autophagy-related protein 17 {ECO:0000303|PubMed:28894236};
GN Name=ATG17 {ECO:0000303|PubMed:28894236};
GN ORFNames=FG06510, FGRAMPH1_01T22473;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
RN [4]
RP IDENTIFICATION, FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28894236; DOI=10.1038/s41598-017-11640-z;
RA Lv W., Wang C., Yang N., Que Y., Talbot N.J., Wang Z.;
RT "Genome-wide functional analysis reveals that autophagy is necessary for
RT growth, sporulation, deoxynivalenol production and virulence in Fusarium
RT graminearum.";
RL Sci. Rep. 7:11062-11062(2017).
CC -!- FUNCTION: Autophagy-specific protein that functions with ATG13, ATG29,
CC and CIS1/ATG31 in response to autophagy-inducing signals as a scaffold
CC to recruit other ATG proteins to organize pre-autophagosomal structure
CC (PAS) formation (By similarity). Modulates the timing and magnitude of
CC the autophagy response, such as the size of the sequestering vesicles,
CC through interacting with and regulating ATG1 kinase activity (By
CC similarity). Plays particularly a role in pexophagy and nucleophagy (By
CC similarity). With ATG13, is required for ATG1 activation by
CC autophosphorylation (By similarity). Recruits ATG9 to the pre-
CC autophagosomal structure (By similarity). Autophagy is required for
CC proper vegetative growth, asexual/sexual reproduction, and full
CC virulence (PubMed:28894236). Autophagy is particularly involved in the
CC biosynthesis of deoxynivalenol (DON), an important virulence
CC determinant (PubMed:28894236). {ECO:0000250|UniProtKB:Q06410,
CC ECO:0000269|PubMed:28894236}.
CC -!- SUBUNIT: Forms a complex with ATG13, ATG29 and CIS1/ATG31 (By
CC similarity). The ATG17-ATG29-ATG31 complex interacts with the ATG1-
CC ATG13 complex (By similarity). Forms a complex with SNX4 and ATG20 (By
CC similarity). Interacts with ATG11 (By similarity).
CC {ECO:0000250|UniProtKB:Q06410}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06410}.
CC Preautophagosomal structure membrane {ECO:0000250|UniProtKB:Q06410};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q06410}.
CC -!- DISRUPTION PHENOTYPE: Does not significantly decrease the growth rate
CC under nutrient-rich conditions (PubMed:28894236).
CC {ECO:0000269|PubMed:28894236}.
CC -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=SCB65064.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; HG970335; SCB65064.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_011326120.1; XM_011327818.1.
DR AlphaFoldDB; I1RR07; -.
DR SMR; I1RR07; -.
DR STRING; 5518.FGSG_06510P0; -.
DR GeneID; 23553640; -.
DR KEGG; fgr:FGSG_06510; -.
DR eggNOG; ENOG502QUHH; Eukaryota.
DR HOGENOM; CLU_028356_0_0_1; -.
DR InParanoid; I1RR07; -.
DR Proteomes; UP000070720; Chromosome 4.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000422; P:autophagy of mitochondrion; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR007240; Atg17.
DR InterPro; IPR045326; ATG17-like_dom.
DR PANTHER; PTHR28005; PTHR28005; 1.
DR Pfam; PF04108; ATG17_like; 1.
PE 3: Inferred from homology;
KW Autophagy; Coiled coil; Cytoplasm; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..519
FT /note="Autophagy-related protein 17"
FT /id="PRO_0000443916"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 324..355
FT /evidence="ECO:0000255"
SQ SEQUENCE 519 AA; 58016 MW; 44739D65C9722D24 CRC64;
MASSSATSLR QGSSGASSGH SHPQSTSLSR HSNSNSNSSR SRSFTHQDVD PNAPSISIDT
LVNHLLVAKR SLSSMTLVLR ANEIANAARQ SHEDVAILAA QAGFLKESIL DQTTILVRVR
RSLQGTYDWG KRDFKKLIRS MDLVDGGLEQ TMEMLRDTSV EGVFRPEGEE RRSLLDFIDE
GGVHGVREAM KKSIQELQSF DGDLLRFDTD IRNLRKIITD TPALTHDDTH FPTFELLEGL
VDHSANMAQL LVSLTHHFDM CVTAIRTTEG GVALARRRAA EVTQTQGNDG VSISGVIAEQ
ESNVSDLEPN TAKDRAEMLK VVVQDAGEVN DVVQEIQERL TAMEQDYLVL QEQHDISKQA
YSNMLEAYAV LGEIGDRLAD YLAAEGDFKS RWDMEKESVF SKLQEMQQLK EFYERYASAY
DSLIIEVERR RAVDDKVKNI WRKAQDSVDK LLDADRASRE TFRQDVGEYL PTDLWAGMQG
SAKKWTVVPD GEGEDVKGPA LRRSVVEGAR ERLGRVERR
