ID   ATG17_KLULA             Reviewed;         423 AA.
AC   Q6CS99;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Autophagy-related protein 17;
GN   Name=ATG17; OrderedLocusNames=KLLA0D02750g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Autophagy-specific protein that functions in response to
CC       autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC       to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC       timing and magnitude of the autophagy response, such as the size of the
CC       sequestering vesicles. Plays particularly a role in pexophagy and
CC       nucleophagy (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00286.1; -; Genomic_DNA.
DR   RefSeq; XP_453190.1; XM_453190.1.
DR   AlphaFoldDB; Q6CS99; -.
DR   SASBDB; Q6CS99; -.
DR   SMR; Q6CS99; -.
DR   DIP; DIP-61493N; -.
DR   IntAct; Q6CS99; 3.
DR   STRING; 28985.XP_453190.1; -.
DR   PRIDE; Q6CS99; -.
DR   EnsemblFungi; CAH00286; CAH00286; KLLA0_D02750g.
DR   GeneID; 2893326; -.
DR   KEGG; kla:KLLA0_D02750g; -.
DR   eggNOG; ENOG502QQDW; Eukaryota.
DR   HOGENOM; CLU_051526_0_0_1; -.
DR   InParanoid; Q6CS99; -.
DR   OMA; YLPENIW; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IEA:EnsemblFungi.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0120095; C:vacuole-isolation membrane contact site; IEA:EnsemblFungi.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:EnsemblFungi.
DR   GO; GO:0030295; F:protein kinase activator activity; IEA:EnsemblFungi.
DR   GO; GO:0000149; F:SNARE binding; IEA:EnsemblFungi.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IEA:EnsemblFungi.
DR   GO; GO:0030242; P:autophagy of peroxisome; IEA:EnsemblFungi.
DR   GO; GO:0044805; P:late nucleophagy; IEA:EnsemblFungi.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IEA:EnsemblFungi.
DR   GO; GO:2000786; P:positive regulation of autophagosome assembly; IEA:EnsemblFungi.
DR   GO; GO:0045772; P:positive regulation of autophagosome size; IEA:EnsemblFungi.
DR   GO; GO:0034497; P:protein localization to phagophore assembly site; IEA:EnsemblFungi.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..423
FT                   /note="Autophagy-related protein 17"
FT                   /id="PRO_0000124561"
SQ   SEQUENCE   423 AA;  49864 MW;  E52905D42DC28C54 CRC64;
     MSDAATTIPS DEIDKLWNKA RNQLVEAQVE CEESLKILSK VRTEMDSSQK SRFKLKFILN
     CLVNQVEFFK NIMLEKCIST ELIDNEWSKL VLVEIVNDVS YWQNEITTKM KILQGTKYDL
     TDDHSSLSDF ICMDHVDILQ QKIDEIPIIK QQVTNIRQHY KSIKDRIENQ LVAVKLKKLR
     TYFDSHFSRD SKNNLFKLLE SDYVTELNEF ENELADFLRS ITDHFDKCTI LKEQQIPLPD
     LKELFQIVKK DDTQLENIRE LVFETGLEVK AFSKKVNETI SEIMDKIGGF HLLASKIVTE
     LEKCEEYLSI FQKIANLVFV YKESCIKKIE QVQQLCEFYD KFKLGYKNLL RERDRRKATA
     LQMEKILKEC QEKLQALSDA DLDQRQQFLL ENGDYLPENI WPGYIDDMES MYSFEYSIHN
     VPN