ID   ATG17_NEOFI             Reviewed;         550 AA.
AC   A1DHW5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Autophagy-related protein 17;
GN   Name=atg17; ORFNames=NFIA_089290;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Autophagy-specific protein that functions in response to
CC       autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC       to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC       timing and magnitude of the autophagy response, such as the size of the
CC       sequestering vesicles. Plays particularly a role in pexophagy and
CC       nucleophagy (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; DS027696; EAW18972.1; -; Genomic_DNA.
DR   RefSeq; XP_001260869.1; XM_001260868.1.
DR   AlphaFoldDB; A1DHW5; -.
DR   SMR; A1DHW5; -.
DR   STRING; 36630.CADNFIAP00008044; -.
DR   EnsemblFungi; EAW18972; EAW18972; NFIA_089290.
DR   GeneID; 4587427; -.
DR   KEGG; nfi:NFIA_089290; -.
DR   VEuPathDB; FungiDB:NFIA_089290; -.
DR   eggNOG; ENOG502RYHP; Eukaryota.
DR   HOGENOM; CLU_028356_0_0_1; -.
DR   OMA; SSINHVW; -.
DR   OrthoDB; 1496047at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IEA:UniProt.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..550
FT                   /note="Autophagy-related protein 17"
FT                   /id="PRO_0000317984"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          317..354
FT                   /evidence="ECO:0000255"
FT   COILED          427..451
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   550 AA;  60647 MW;  DC9C599347F8D55F CRC64;
     MSSSESSSAS GGGRPDAGQP PSEEQAMPRL DTLISHLVAA KRSLSSINHV WRANEIVTAA
     RAALEECVVV SARTGFLRRG LNNQLRLLYS VRTEVEEISL RGRSEFAAVL KDLDDADTRL
     RRTLELLRET IVHPAFRPEG EDPKSLHDFV DERGVEELHA ALKSSIDRTT AAQAQLDSSN
     HAFDDELLSI KEALGTYRTA AKLASSRSSS SASSSSASNS SLPSMSTMPS MLHSLEMHAQ
     EMANLLESLV RHFDLCVTAV KHTEGGGAAA KSITGDMPVG VPVSGRMGSN IEDINDNLNA
     PLDPLSNSEY QEMVNVLFKD AAEAEDVVME IQDRISEMES VLENVLAQRD ALRSIYNATT
     DIYQHLSSLG STRLPGYIAQ AHNFTQVWHE ENDRISGGLA DLSDLNSLYD GFLDAYDGLI
     VEVARRKHVR QRVEKVLRDA RHKLDQLYEE DVTARETFRV EKGDYLPSDI WPEIGREPMR
     IEFRRISGAN VQAVNLQRPH EQEAITGEQE AANRLAPVES SDGDEIIPDL PRDLVEQAFA
     RLKARVKGAT