ID   ATG17_PENRW             Reviewed;         554 AA.
AC   A7KAM6; B6GZA0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Autophagy-related protein 17;
GN   Name=atg17; ORFNames=Pc12g12840;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=17204848; DOI=10.4161/auto.3595;
RA   Meijer W.H., van der Klei I.J., Veenhuis M., Kiel J.A.K.W.;
RT   "ATG genes involved in non-selective autophagy are conserved from yeast to
RT   man, but the selective Cvt and pexophagy pathways also require organism-
RT   specific genes.";
RL   Autophagy 3:106-116(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Autophagy-specific protein that functions in response to
CC       autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC       to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC       timing and magnitude of the autophagy response, such as the size of the
CC       sequestering vesicles. Plays particularly a role in pexophagy and
CC       nucleophagy (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:17204848}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; EF110892; ABO31313.1; -; Genomic_DNA.
DR   EMBL; AM920427; CAP80911.1; -; Genomic_DNA.
DR   RefSeq; XP_002558092.1; XM_002558046.1.
DR   AlphaFoldDB; A7KAM6; -.
DR   SMR; A7KAM6; -.
DR   STRING; 1108849.XP_002558092.1; -.
DR   EnsemblFungi; CAP80911; CAP80911; PCH_Pc12g12840.
DR   GeneID; 8317407; -.
DR   KEGG; pcs:Pc12g12840; -.
DR   VEuPathDB; FungiDB:PCH_Pc12g12840; -.
DR   eggNOG; ENOG502RYHP; Eukaryota.
DR   HOGENOM; CLU_028356_0_0_1; -.
DR   OMA; SSINHVW; -.
DR   OrthoDB; 1496047at2759; -.
DR   BioCyc; PCHR:PC12G12840-MON; -.
DR   Proteomes; UP000000724; Contig Pc00c12.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IEA:UniProt.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..554
FT                   /note="Autophagy-related protein 17"
FT                   /id="PRO_0000317985"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          490..529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          327..353
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   554 AA;  60713 MW;  490E42A25D101700 CRC64;
     MASSQSSSSS IRPQAGLNEG DHQSLPQLDT LISYLLGAKR SLSSITHVWR ANEIVTASHS
     ALEKSVVLCS RTGFLRRGLN GQLRLLYDVR SEVEQISYRG RDEFSIALKN LDAADARLKH
     TLDLLRGTIV HASFRPGDEE QKSLHDFVDE RGVEELHASL KASIDRTNTA RAELDTSNHE
     FDDELQAIKK SLRHYHTATK LASSRLSITS SSSSASDSGL LTLSSMPGQI QSLEAHAQEM
     ATLLEALVRH FDLCVTAVKH TDGGGAVARS ITGDMPAGVD GSNDGMPNIG AEINANLNAP
     LDPMTDAEYQ EMVAVLIKDA PEADDVVMEI QDRINEMESI FEQVQAQRDA LLSISKATIE
     VHSHLSSLAS SRLPRYISQA HNFTRVWLEE NDRINSGLVE LSDLHSLYDG FLNAYDSLML
     EVARRRHVRQ RVEKVLRDTR HKLDQLHDED AAARETFRAE QGDFLPSDIW PGVGLAPMQV
     QFTRLSGGQL DGGPIGQKPL EEPSGGEYAG AAKAGVSDGS AEGEQIPDLP RHLVEEAYAR
     VKARNKVASQ LHTV