ID   ATG17_PICAN             Reviewed;         429 AA.
AC   A7KAK1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Autophagy-related protein 17;
GN   Name=ATG17;
OS   Pichia angusta (Yeast) (Hansenula polymorpha).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Ogataea.
OX   NCBI_TaxID=870730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL
RC   Y-5445;
RX   PubMed=17204848; DOI=10.4161/auto.3595;
RA   Meijer W.H., van der Klei I.J., Veenhuis M., Kiel J.A.K.W.;
RT   "ATG genes involved in non-selective autophagy are conserved from yeast to
RT   man, but the selective Cvt and pexophagy pathways also require organism-
RT   specific genes.";
RL   Autophagy 3:106-116(2007).
CC   -!- FUNCTION: Autophagy-specific protein that functions in response to
CC       autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC       to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC       timing and magnitude of the autophagy response, such as the size of the
CC       sequestering vesicles. Plays particularly a role in pexophagy and
CC       nucleophagy (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:17204848}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; EF107723; ABO31061.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7KAK1; -.
DR   SMR; A7KAK1; -.
DR   PRIDE; A7KAK1; -.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IEA:UniProt.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane.
FT   CHAIN           1..429
FT                   /note="Autophagy-related protein 17"
FT                   /id="PRO_0000317986"
FT   COILED          146..175
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   429 AA;  49398 MW;  F42E1C41F7C05F70 CRC64;
     MAIPIAQWVA DARANLAHAE QVCNDANMYL TSTSEKLRRR EMKVPKLIYY LDALKQQLRL
     LEIIRDSLVL NLNGVMEKRA ALQSQLLKDV DRLHQTIDTL KNTVVVFDGQ TTLYEYISES
     GVEELFNGVS QNLKDIQTLI KGNRTDALLI RLTSDLDHLS NELNALDSKF RDMRLVDTQS
     SSIDPISKLL EINAELEHDM VAILTSFNNH YDQCEKGEAI LKDPAVPQDE KDELVSVLQN
     DVEELPEAQR SLTSNAEIIK KNCKEVMKIL DIFEDYFQRV ETYVCELQEY GESKLRVQLK
     EFSDINTEVS RKLEIAQTHQ DELVQYNSDF QQFVRSYYSL ILELDRRMRV NEHISSAIDN
     FRSTISNIVE KDHEKRMEFL QKHGDFIPQN LVDSSVINSG TPQISINFDQ EPLPAISKEV
     VQLAKKMQK