ID   ATG17_PICST             Reviewed;         483 AA.
AC   A3LX29;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Autophagy-related protein 17;
GN   Name=ATG17; ORFNames=PICST_61658;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Autophagy-specific protein that functions in response to
CC       autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC       to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC       timing and magnitude of the autophagy response, such as the size of the
CC       sequestering vesicles. Plays particularly a role in pexophagy and
CC       nucleophagy (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; CP000500; ABN67728.2; -; Genomic_DNA.
DR   RefSeq; XP_001385757.2; XM_001385720.1.
DR   AlphaFoldDB; A3LX29; -.
DR   SMR; A3LX29; -.
DR   STRING; 4924.XP_001385757.2; -.
DR   EnsemblFungi; ABN67728; ABN67728; PICST_61658.
DR   GeneID; 4840303; -.
DR   KEGG; pic:PICST_61658; -.
DR   eggNOG; ENOG502RW77; Eukaryota.
DR   HOGENOM; CLU_565132_0_0_1; -.
DR   InParanoid; A3LX29; -.
DR   OMA; QCMKAVE; -.
DR   OrthoDB; 1496047at2759; -.
DR   Proteomes; UP000002258; Chromosome 6.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IEA:UniProt.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..483
FT                   /note="Autophagy-related protein 17"
FT                   /id="PRO_0000317987"
FT   COILED          136..161
FT                   /evidence="ECO:0000255"
FT   COILED          206..235
FT                   /evidence="ECO:0000255"
FT   COILED          446..483
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   483 AA;  55710 MW;  08E3D4149237F1BD CRC64;
     MHATVDRATV TAWAKQAQST LEKAQTLCTN AQTSLHATSY QLTSHLPDLL EEANVLYESL
     KTQHELLAKI SESLRRSIRD QLLNTLEKQQ STLLQPALNN LDDIVGHLSA TIVPSFLIEK
     DEAENRTLAD FISTDSINLL RRNIQIYTNN HEKIRQLLNN KLQDVILSPF HEIGSKKFNK
     TVKLYEEITP LQLKLKAITS NIAPLDSSNV VATLLKENAA LENELVSILE MLTNHYDQCT
     QGVQILYSGG SQQVNLEILK NDAQELPDVL KELHTVYDII VNNEARAQKF INAHSPSIEV
     VIATMKDQLS FYRSFKSKNI PEIMVLFTVC EEILMKSPIE DPGGPEQTPI EKFTDTVNQL
     VYHYTQFLNV FKSQYLRELH HEQFSYPRKF LSKLTNFLND ELYKMQIEEK ERRRAWLTKY
     GDFIPKEFRL PGEYNQPVIT QVVTEGLEDV QKEGADAERH ITQEKELLEL LRKMEELNRE
     RRY