ID   ATG17_VANPO             Reviewed;         413 AA.
AC   A7TM40;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Autophagy-related protein 17;
GN   Name=ATG17; ORFNames=Kpol_1052p29;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Autophagy-specific protein that functions in response to
CC       autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC       to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC       timing and magnitude of the autophagy response, such as the size of the
CC       sequestering vesicles. Plays particularly a role in pexophagy and
CC       nucleophagy (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; DS480419; EDO16682.1; -; Genomic_DNA.
DR   RefSeq; XP_001644540.1; XM_001644490.1.
DR   AlphaFoldDB; A7TM40; -.
DR   SMR; A7TM40; -.
DR   STRING; 436907.A7TM40; -.
DR   EnsemblFungi; EDO16682; EDO16682; Kpol_1052p29.
DR   GeneID; 5544838; -.
DR   KEGG; vpo:Kpol_1052p29; -.
DR   eggNOG; ENOG502QQDW; Eukaryota.
DR   HOGENOM; CLU_051526_0_0_1; -.
DR   InParanoid; A7TM40; -.
DR   OMA; YLPENIW; -.
DR   OrthoDB; 1496047at2759; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IEA:UniProt.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..413
FT                   /note="Autophagy-related protein 17"
FT                   /id="PRO_0000317989"
SQ   SEQUENCE   413 AA;  48447 MW;  DB5C313718157BF3 CRC64;
     MKIERFVNAS RKTLVEAQVL CQDANSRISN ARSSFSHWER SISKIRFLLN CLKNQGSFIK
     NCILKVGIEE NLIEKEWTQS ILVDLAKELK YWNSKINEQV RVLDSIENIL DEDTKSESKN
     LGYFVSRDNL DILEKRLKEI PNVKYHIDNI RGQYNTMFKK VSNYLINKRL KSVQEYFLTN
     FENDSDDIKK LTTTLPSKLV SLEHDLADYL SSITNHYDQS KLLQTLKPAD PDYTDLLEVV
     KNDNSELDGI VTLLRETVDE VDETLKTFLG IFNEIELKQK ECNKLLFGVI EEFKINHEYL
     LIFNDISSLI DNFKETCIED INNTRSLCIF YQKFEIGYQN LLFEIERRKT VAQKMTDIIK
     NCELELSKIN EEDQKNRSEF LKLNGDYLPE NIWPGKIDDF SPLYSLEYSI KEI