ID   ATG17_YARLI             Reviewed;         408 AA.
AC   Q6C0L6;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Autophagy-related protein 17;
GN   Name=ATG17; OrderedLocusNames=YALI0F23639g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Autophagy-specific protein that functions in response to
CC       autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC       to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC       timing and magnitude of the autophagy response, such as the size of the
CC       sequestering vesicles. Plays particularly a role in pexophagy and
CC       nucleophagy (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78607.1; -; Genomic_DNA.
DR   RefSeq; XP_505796.1; XM_505796.1.
DR   AlphaFoldDB; Q6C0L6; -.
DR   SMR; Q6C0L6; -.
DR   STRING; 4952.CAG78607; -.
DR   EnsemblFungi; CAG78607; CAG78607; YALI0_F23639g.
DR   GeneID; 2908761; -.
DR   KEGG; yli:YALI0F23639g; -.
DR   VEuPathDB; FungiDB:YALI0_F23639g; -.
DR   HOGENOM; CLU_565132_0_0_1; -.
DR   InParanoid; Q6C0L6; -.
DR   OMA; WRANDIV; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:1990316; C:Atg1/ULK1 kinase complex; IBA:GO_Central.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0030242; P:autophagy of peroxisome; IBA:GO_Central.
DR   GO; GO:0044805; P:late nucleophagy; IBA:GO_Central.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..408
FT                   /note="Autophagy-related protein 17"
FT                   /id="PRO_0000124565"
SQ   SEQUENCE   408 AA;  46433 MW;  F43FC0CD62D01880 CRC64;
     MEQLFREAQD ALAAAGPLCQ ESQDVLARAR QNLEVAVHLG IRTQFLAKAH AHQWTLASKF
     YSNALTRTKK SLETVTRQQT RFQAARGALE EALGELAATP VQLRVNNGAH NLREFVDEDL
     ISAQVQGKGW NEVHEEALNV FRVLLPEIQR HGDIVNRSKK EFEREKAEQT ELLIHQTSDS
     GIYDLLNSAE ACSEDMANLL QSLARHYDLC ERGQDLSTGA IEAEDVNELG ELRAVLENDA
     QQLPDVLDEL QERLDEVKQG CQGVHNHMTQ MYHSYSLEVR QLEGIQAVEK TMDATLEICE
     TQQRDTKEYL LKVQRYVSET SAVVTHYQTF LNSYKALLHE AERRNAAEAK MKDYVTEVNA
     KLAQMSIQET NRRQDFVAQQ GDYLPADIWD ELLLPSRRFE ARELDGEL