ID   ATG17_YEAS7             Reviewed;         417 AA.
AC   A7A1U4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Autophagy-related protein 17;
GN   Name=ATG17; Synonyms=APG17; ORFNames=SCY_3972;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Autophagy-specific protein that functions with ATG13, ATG29,
CC       and CIS1/ATG31 in response to autophagy-inducing signals as a scaffold
CC       to recruit other ATG proteins to organize pre-autophagosomal structure
CC       (PAS) formation. Modulates the timing and magnitude of the autophagy
CC       response, such as the size of the sequestering vesicles, through
CC       interacting with and regulating ATG1 kinase activity. Plays
CC       particularly a role in pexophagy and nucleophagy. With ATG13, is
CC       required for ATG1 activation by autophosphorylation of 'Thr-226'.
CC       Recruits ATG9 to the pre-autophagosomal structure. Also plays a role in
CC       regulation of filamentous growth (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with ATG13, ATG29 and CIS1/ATG31. The ATG17-
CC       ATG29-ATG31 complex interacts with the ATG1-ATG13 complex. Forms a
CC       complex with SNX4 and ATG20. Interacts with ATG11 and the conserved
CC       oligomeric Golgi (COG) complex subunits COG1, COG3 and COG4.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR   EMBL; AAFW02000171; EDN59322.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7A1U4; -.
DR   SMR; A7A1U4; -.
DR   PRIDE; A7A1U4; -.
DR   EnsemblFungi; EDN59322; EDN59322; SCY_3972.
DR   HOGENOM; CLU_051526_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IEA:UniProt.
DR   InterPro; IPR007240; Atg17.
DR   InterPro; IPR045326; ATG17-like_dom.
DR   PANTHER; PTHR28005; PTHR28005; 1.
DR   Pfam; PF04108; ATG17_like; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane.
FT   CHAIN           1..417
FT                   /note="Autophagy-related protein 17"
FT                   /id="PRO_0000317990"
FT   COILED          146..221
FT                   /evidence="ECO:0000255"
FT   COILED          353..384
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   417 AA;  48639 MW;  356298DF5EF63852 CRC64;
     MNEADVTKFV NNARKTLTDA QLLCSSANLR IVDIKKKLSS WQLSISKLNF LIVGLRQQGK
     FLYTILKEGI GTKLIQKQWN QAVLVVLVDE MKYWQYEITS KVQRLDGIVN ELSISEKDDT
     DPSKLGDYIS RDNVNLLNDK LKEVPVIERQ IENIKLQYEN MVRKVNKELI DTKLTDVTQK
     FQSKFGIDNL METNVAEQFS RELTDLEKDL AEIMNSLTQH FDKTLLLQDK KIDNDEREEL
     FKVVQGDDKE LFNIFKTLHE VIDDVNKTIL NLGQFLQAKI KEKTELHSEV SEIINDFNRN
     LEYLLIFKDI SNLIDSFKNS CTQDIQTTKE LCEFYDNFEE SYGNLVLEAK RRKDVANRMK
     TILKDCEKQL QNLDAQDQEE RQNFIAENGT YLPETIWPGK IDDFSSLYTL NYNVKNP