ID   AAAP_ANAMF              Reviewed;         324 AA.
AC   Q5SF95; B9KJ36;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Appendage-associated protein;
DE   Flags: Precursor;
GN   Name=aaaP1; OrderedLocusNames=AMF_659;
GN   and
GN   Name=aaaP2; OrderedLocusNames=AMF_663;
OS   Anaplasma marginale (strain Florida).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Anaplasma.
OX   NCBI_TaxID=320483;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAS83465.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=15557651; DOI=10.1128/iai.72.12.7257-7264.2004;
RA   Stich R.W., Olah G.A., Brayton K.A., Brown W.C., Fecheimer M.,
RA   Green-Church K., Jittapalapong S., Kocan K.M., McGuire T.C.,
RA   Rurangirwa F.R., Palmer G.H.;
RT   "Identification of a novel Anaplasma marginale appendage-associated protein
RT   that localizes with actin filaments during intraerythrocytic infection.";
RL   Infect. Immun. 72:7257-7264(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Florida;
RX   PubMed=19134224; DOI=10.1186/1471-2164-10-16;
RA   Dark M.J., Herndon D.R., Kappmeyer L.S., Gonzales M.P., Nordeen E.,
RA   Palmer G.H., Knowles D.P. Jr., Brayton K.A.;
RT   "Conservation in the face of diversity: multistrain analysis of an
RT   intracellular bacterium.";
RL   BMC Genomics 10:16-16(2009).
CC   -!- FUNCTION: Associates with actin filament appendages that are formed in
CC       the inclusion appendages of the parasitophorous vacuole during
CC       infection of the host erythrocyte. {ECO:0000269|PubMed:15557651}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15557651}.
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DR   EMBL; AY514451; AAS83465.1; -; Genomic_DNA.
DR   EMBL; CP001079; ACM49498.1; -; Genomic_DNA.
DR   EMBL; CP001079; ACM49501.1; -; Genomic_DNA.
DR   RefSeq; WP_012659037.1; NC_012026.1.
DR   AlphaFoldDB; Q5SF95; -.
DR   STRING; 320483.AMF_659; -.
DR   EnsemblBacteria; ACM49498; ACM49498; AMF_659.
DR   EnsemblBacteria; ACM49501; ACM49501; AMF_663.
DR   GeneID; 7397847; -.
DR   KEGG; amf:AMF_659; -.
DR   KEGG; amf:AMF_663; -.
DR   PATRIC; fig|320483.3.peg.758; -.
DR   HOGENOM; CLU_856975_0_0_5; -.
DR   OrthoDB; 2126489at2; -.
DR   Proteomes; UP000007307; Chromosome.
DR   GO; GO:0020003; C:symbiont-containing vacuole; IDA:UniProtKB.
DR   GO; GO:0051015; F:actin filament binding; IDA:UniProtKB.
DR   GO; GO:0051701; P:biological process involved in interaction with host; IDA:UniProtKB.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000250|UniProtKB:Q5SF96"
FT   CHAIN           33..324
FT                   /note="Appendage-associated protein"
FT                   /evidence="ECO:0000250|UniProtKB:Q5SF96"
FT                   /id="PRO_0000258015"
FT   COILED          195..255
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   324 AA;  34908 MW;  48D24D13ECF20068 CRC64;
     MGCPVSRGGS PGCGRRIAEE LRLAEDARLR LALLGRCIVK GSPAQVRKEL RAELKAIDAE
     WRPVIARESL RKELDAIDAE WQHAITFWHI SRAIIGSIEL SKELDAIDAE WRPVIVRESL
     RKELKAIDAE WRPAIRLESA YRAIIGSIEL SKELKAIDAE TQHAVELRRA LRTIEGRIEL
     SRELKAIDAE WAPRIAQAKE IAQARESLRK ELNDIDAEWA PKIAQAKEIA QAKAELAAAT
     DALKRAADKL QALGKMGTTS TPGTDLIGVV TTAVTTTLAG TQPAPGTDLV GVATPSTALG
     QPAPSTALTS VAAEVATPST ALGV