ID   ATG18_DICDI             Reviewed;         372 AA.
AC   Q54NA2;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Autophagy-related protein 18;
DE   AltName: Full=WD repeat domain phosphoinositide-interacting protein 2 homolog;
GN   Name=atg18; Synonyms=wipi2; ORFNames=DDB_G0285375;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May be involved in cytoplasm to vacuole transport and
CC       autophagy. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Vacuole
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PROPPIN family. {ECO:0000305}.
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DR   EMBL; AAFI02000079; EAL64762.1; -; Genomic_DNA.
DR   RefSeq; XP_638278.1; XM_633186.1.
DR   AlphaFoldDB; Q54NA2; -.
DR   SMR; Q54NA2; -.
DR   STRING; 44689.DDB0235215; -.
DR   PaxDb; Q54NA2; -.
DR   EnsemblProtists; EAL64762; EAL64762; DDB_G0285375.
DR   GeneID; 8625086; -.
DR   KEGG; ddi:DDB_G0285375; -.
DR   dictyBase; DDB_G0285375; atg18.
DR   eggNOG; KOG2110; Eukaryota.
DR   HOGENOM; CLU_025895_5_2_1; -.
DR   InParanoid; Q54NA2; -.
DR   OMA; PSRDFAW; -.
DR   PhylomeDB; Q54NA2; -.
DR   Reactome; R-DDI-1632852; Macroautophagy.
DR   PRO; PR:Q54NA2; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005829; C:cytosol; ISS:dictyBase.
DR   GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IBA:GO_Central.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035091; F:phosphatidylinositol binding; ISS:dictyBase.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:GO_Central.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; ISS:dictyBase.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0044804; P:autophagy of nucleus; IBA:GO_Central.
DR   GO; GO:0006497; P:protein lipidation; IBA:GO_Central.
DR   GO; GO:0034497; P:protein localization to phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Autophagy; Membrane; Protein transport; Reference proteome; Repeat;
KW   Transport; Vacuole; WD repeat.
FT   CHAIN           1..372
FT                   /note="Autophagy-related protein 18"
FT                   /id="PRO_0000342025"
FT   REPEAT          176..216
FT                   /note="WD 1"
FT   REPEAT          221..260
FT                   /note="WD 2"
SQ   SEQUENCE   372 AA;  40577 MW;  736E9215F61C1212 CRC64;
     MNVGGKFNEG ILFLNFNQDF SCIAVGTPEG YKIFNSDPYT LYYSQSNGGA GLVEMLFSTS
     LVSIVGSGDG NTSQRRLLIN NIKNNIPICD LNFVTAILSV KMNRKRIVVI METKIHIYDI
     NNMKLLETRE IASNPKGLCA LSPSNTNYIV YPASQNNGNI LVMDVLTLET VNLIQAHKSQ
     ISALALSQDG TLLATASDKG TVIRVFALPY ANKSLSFRRG SIPAIIHSMT FSLDGRYLCV
     SSDTGTIHIF KIDFSSSNSS SFHQAQPSSS PSGGMMGLNF GGLTSKMSSY LPEVISQVWE
     PSRDFAHIKI PPGIPSICAL MQNNKTAMVL TADSLYMQYN FDESVGGELK LAKEFSLLME
     PDLDNDVTAK IL