ID   PRMB_SALTI              Reviewed;         310 AA.
AC   P0A294; P39201;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=50S ribosomal protein L3 glutamine methyltransferase {ECO:0000255|HAMAP-Rule:MF_02125};
DE            Short=L3 MTase {ECO:0000255|HAMAP-Rule:MF_02125};
DE            EC=2.1.1.298 {ECO:0000255|HAMAP-Rule:MF_02125};
DE   AltName: Full=N5-glutamine methyltransferase PrmB {ECO:0000255|HAMAP-Rule:MF_02125};
GN   Name=prmB {ECO:0000255|HAMAP-Rule:MF_02125}; Synonyms=yfcB;
GN   OrderedLocusNames=STY2617, t0479;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 225-310.
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=2182772; DOI=10.1099/00221287-136-2-353;
RA   Charles I.G., Lamb H.K., Pickard D., Dougan G., Hawkins A.R.;
RT   "Isolation, characterization and nucleotide sequences of the aroC genes
RT   encoding chorismate synthase from Salmonella typhi and Escherichia coli.";
RL   J. Gen. Microbiol. 136:353-358(1990).
RN   [4]
RP   IDENTIFICATION, AND CONCEPTUAL TRANSLATION.
RX   PubMed=7984428; DOI=10.1093/nar/22.22.4756;
RA   Borodovsky M., Rudd K.E., Koonin E.V.;
RT   "Intrinsic and extrinsic approaches for detecting genes in a bacterial
RT   genome.";
RL   Nucleic Acids Res. 22:4756-4767(1994).
CC   -!- FUNCTION: Specifically methylates the 50S ribosomal protein L3 on 'Gln-
CC       150'. {ECO:0000255|HAMAP-Rule:MF_02125}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine
CC         = H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-
CC         adenosyl-L-homocysteine; Xref=Rhea:RHEA:45020, Rhea:RHEA-COMP:11063,
CC         Rhea:RHEA-COMP:11064, ChEBI:CHEBI:15378, ChEBI:CHEBI:30011,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61891;
CC         EC=2.1.1.298; Evidence={ECO:0000255|HAMAP-Rule:MF_02125};
CC   -!- SIMILARITY: Belongs to the protein N5-glutamine methyltransferase
CC       family. PrmB subfamily. {ECO:0000255|HAMAP-Rule:MF_02125}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=Ref.3; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AL513382; CAD07617.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO68186.1; -; Genomic_DNA.
DR   RefSeq; NP_456926.1; NC_003198.1.
DR   RefSeq; WP_001542329.1; NZ_UCTX01000013.1.
DR   AlphaFoldDB; P0A294; -.
DR   SMR; P0A294; -.
DR   STRING; 220341.16503608; -.
DR   EnsemblBacteria; AAO68186; AAO68186; t0479.
DR   KEGG; stt:t0479; -.
DR   KEGG; sty:STY2617; -.
DR   PATRIC; fig|220341.7.peg.2650; -.
DR   eggNOG; COG2890; Bacteria.
DR   HOGENOM; CLU_018398_5_1_6; -.
DR   OMA; IYYGHGT; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0036009; F:protein-glutamine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:InterPro.
DR   GO; GO:0018364; P:peptidyl-glutamine methylation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.150; -; 1.
DR   HAMAP; MF_02125; L3_methyltr_PrmB; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR004556; HemK-like.
DR   InterPro; IPR017127; Ribosome_L3_Gln-N5_MeTrfase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR007848; Small_mtfrase_dom.
DR   Pfam; PF05175; MTS; 1.
DR   PIRSF; PIRSF037167; Mtase_YfcB_prd; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00536; hemK_fam; 1.
DR   TIGRFAMs; TIGR03533; L3_gln_methyl; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..310
FT                   /note="50S ribosomal protein L3 glutamine
FT                   methyltransferase"
FT                   /id="PRO_0000088004"
SQ   SEQUENCE   310 AA;  35064 MW;  0205E269AEA28638 CRC64;
     MDKIFVDEAV SELHTIQDML RWAVSRFSAA NIWYGHGTDN PWDEAVQLVL PSLYLPLDIP
     EDMRTARLTS SEKHRIVERV IRRINERIPV AYLTNKAWFC GHEFYVDERV LVPRSPIGEL
     INNHFAGLIS QQPKYILDMC TGSGCIAIAC AYAFPDAEVD AVDISPDALA VAEHNIEEHG
     LIHHVTPIRS DLFRDLPKVQ YDLIVTNPPY VDAEDMSDLP NEYRHEPELG LASGTDGLKL
     TRRILGNAPD YLSDDGVLIC EVGNSMVHLM EQYPDVPFTW LEFDNGGDGV FMLTKAQLLA
     AREHFNIYKD