ID   PRMC_RHOJR              Reviewed;         368 AA.
AC   Q0SJK7;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Propane 2-monooxygenase, hydroxylase component small subunit {ECO:0000303|PubMed:17873074};
DE            Short=PrMO {ECO:0000303|PubMed:17873074};
DE            EC=1.14.13.227 {ECO:0000305|PubMed:17873074};
GN   Name=prmC {ECO:0000303|PubMed:17873074};
GN   OrderedLocusNames=RHA1_ro00443 {ECO:0000312|EMBL:ABG92279.1};
OS   Rhodococcus jostii (strain RHA1).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=101510;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHA1 {ECO:0000312|Proteomes:UP000008710};
RX   PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA   McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C.,
RA   Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H.,
RA   Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H.,
RA   Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R.,
RA   Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W.,
RA   Eltis L.D.;
RT   "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT   catabolic powerhouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
RN   [2]
RP   FUNCTION, CATALYTIC ACTIVITY, INDUCTION BY PROPANE, SUBSTRATE SPECIFICITY,
RP   AND SUBUNIT.
RC   STRAIN=RHA1;
RX   PubMed=17873074; DOI=10.1128/aem.01697-07;
RA   Sharp J.O., Sales C.M., LeBlanc J.C., Liu J., Wood T.K., Eltis L.D.,
RA   Mohn W.W., Alvarez-Cohen L.;
RT   "An inducible propane monooxygenase is responsible for N-
RT   nitrosodimethylamine degradation by Rhodococcus sp. strain RHA1.";
RL   Appl. Environ. Microbiol. 73:6930-6938(2007).
RN   [3]
RP   SUBUNIT.
RX   PubMed=23171424; DOI=10.1111/febs.12070;
RA   Furuya T., Hayashi M., Semba H., Kino K.;
RT   "The mycobacterial binuclear iron monooxygenases require a specific
RT   chaperonin-like protein for functional expression in a heterologous host.";
RL   FEBS J. 280:817-826(2013).
CC   -!- FUNCTION: Component of the propane 2-monooxygenase multicomponent
CC       enzyme system which is involved in the degradation of propane via the
CC       O2-dependent hydroxylation of propane. Also able to catalyze the
CC       oxidation the water contaminant N-nitrosodimethylamine (NDMA).
CC       {ECO:0000269|PubMed:17873074}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + NADH + O2 + propane = H2O + NAD(+) + propan-2-ol;
CC         Xref=Rhea:RHEA:49992, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:17824, ChEBI:CHEBI:32879,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.14.13.227;
CC         Evidence={ECO:0000305|PubMed:17873074};
CC   -!- SUBUNIT: The propane 2-monooxygenase multicomponent enzyme system is
CC       composed of an electron transfer component and a monooxygenase
CC       component interacting with the effector protein PrmD. The electron
CC       transfer component is composed of a reductase (PrmB), and the
CC       monooxygenase component is formed by a large subunit (PrmA) and a small
CC       subunit (PrmC) (PubMed:17873074). Probably requires the presence of the
CC       chaperonin-like protein PrmG to ensure a productive folding, resulting
CC       of a soluble PrmC, which leads to the active form of PrmABCD
CC       (PubMed:23171424). {ECO:0000305|PubMed:17873074,
CC       ECO:0000305|PubMed:23171424}.
CC   -!- INDUCTION: By propane. {ECO:0000269|PubMed:17873074}.
CC   -!- SIMILARITY: Belongs to the TmoE/XamoE family. {ECO:0000305}.
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DR   EMBL; CP000431; ABG92279.1; -; Genomic_DNA.
DR   RefSeq; WP_011593716.1; NC_008268.1.
DR   AlphaFoldDB; Q0SJK7; -.
DR   SMR; Q0SJK7; -.
DR   STRING; 101510.RHA1_ro00443; -.
DR   EnsemblBacteria; ABG92279; ABG92279; RHA1_ro00443.
DR   KEGG; rha:RHA1_ro00443; -.
DR   PATRIC; fig|101510.16.peg.471; -.
DR   eggNOG; ENOG502Z7Z9; Bacteria.
DR   HOGENOM; CLU_061948_1_0_11; -.
DR   OMA; QGWIYGF; -.
DR   Proteomes; UP000008710; Chromosome.
DR   GO; GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   GO; GO:0006725; P:cellular aromatic compound metabolic process; IEA:InterPro.
DR   CDD; cd01058; AAMH_B; 1.
DR   Gene3D; 1.10.620.20; -; 1.
DR   InterPro; IPR009078; Ferritin-like_SF.
DR   InterPro; IPR012078; MP_mOase_hydro.
DR   InterPro; IPR003430; Phenol_Hydrox.
DR   InterPro; IPR012348; RNR-like.
DR   Pfam; PF02332; Phenol_Hydrox; 1.
DR   PIRSF; PIRSF000040; MMOH_comp; 1.
DR   SUPFAM; SSF47240; SSF47240; 1.
PE   1: Evidence at protein level;
KW   Monooxygenase; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..368
FT                   /note="Propane 2-monooxygenase, hydroxylase component small
FT                   subunit"
FT                   /id="PRO_0000442965"
SQ   SEQUENCE   368 AA;  41696 MW;  8EA9E993666E13B3 CRC64;
     MTATAESKQR SFPKIEFTDS EAGALEFPSS RSRTFTYYTP AKKRSTMYED VTVDVQPDPD
     RHLSQGWIYG FGDGPGGYPQ EWTAAKSSNW HAFLDPNEEW DQTIYRNNSK VVHQVELCLS
     NAKRARVYDG WNTPWLTFIS RNLGAWMHAE NGLALHVFTS IQRSCPTNMI NTAVAVNAAH
     KMRFAQDLAL FNLDLSEATE NFDGTAHKEV WQSAPEWQPT REVVERLTAV PDWCELLFGS
     NIVFEQLVGT LFRSELVMQI AAGNGDYITP TIVGTGEHDY DRDLAYTRNL FRLLTRDPEH
     GEANKELFGT WLAIWVPRCL DAARALQPIW SQPADKAITF ATSFDAATDK FRSLLEDLGL
     DIPKELDQ