PRO1_CAEBR
ID PRO1_CAEBR Reviewed; 532 AA.
AC A8WSU9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Pre-rRNA-processing protein pro-1;
DE AltName: Full=Proximal proliferation in germline protein 1;
GN Name=pro-1; ORFNames=CBG03075;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Component of the PELP1 complex involved in the nucleolar
CC steps of 28S rRNA maturation and the subsequent nucleoplasmic transit
CC of the pre-60S ribosomal subunit (By similarity). Required for
CC processing ITS2 sequences from rRNA intermediates during 26S rRNA
CC maturation (By similarity). Required in the soma to promote normal
CC proliferation and prevent germline tumor formation (By similarity).
CC {ECO:0000250|UniProtKB:Q22006, ECO:0000250|UniProtKB:Q9BV38}.
CC -!- SUBUNIT: Component of the PELP1 complex, composed of at least PELP1,
CC TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.
CC {ECO:0000250|UniProtKB:Q9BV38}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9BV38}. Nucleus, nucleoplasm
CC {ECO:0000250|UniProtKB:Q4VBE8}.
CC -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR EMBL; HE601438; CAP23558.1; -; Genomic_DNA.
DR RefSeq; XP_002631267.1; XM_002631221.1.
DR AlphaFoldDB; A8WSU9; -.
DR SMR; A8WSU9; -.
DR STRING; 6238.CBG03075; -.
DR EnsemblMetazoa; CBG03075.1; CBG03075.1; WBGene00026011.
DR GeneID; 8572782; -.
DR KEGG; cbr:CBG_03075; -.
DR CTD; 8572782; -.
DR WormBase; CBG03075; CBP14498; WBGene00026011; Cbr-pro-1.
DR eggNOG; KOG0646; Eukaryota.
DR HOGENOM; CLU_038304_0_0_1; -.
DR InParanoid; A8WSU9; -.
DR OMA; EISSHQC; -.
DR OrthoDB; 600866at2759; -.
DR Proteomes; UP000008549; Chromosome II.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR GO; GO:0007281; P:germ cell development; IEA:EnsemblMetazoa.
DR GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR045227; WDR18/Ipi3/RID3.
DR PANTHER; PTHR18763; PTHR18763; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil; Developmental protein; Differentiation;
KW Gonadal differentiation; Nucleus; Reference proteome; Repeat;
KW Ribosome biogenesis; rRNA processing; WD repeat.
FT CHAIN 1..532
FT /note="Pre-rRNA-processing protein pro-1"
FT /id="PRO_0000315876"
FT REPEAT 136..175
FT /note="WD 1"
FT REPEAT 287..326
FT /note="WD 2"
FT REGION 435..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 445..526
FT /evidence="ECO:0000255"
SQ SEQUENCE 532 AA; 59135 MW; 534B8DF6A5C9C13D CRC64;
MAYLGVDTSR IAGTQPLEML LISSSSPDPH STIIIDPRTG VSSWSYKGGE LQGASTGLVE
PLGKDGEHIV VTTKDRPLVH VIAVHSKDRF HQKCVLPGPV SAICSDRSGR FAFMSIKRQL
YCWLLSTGEL LSVIDAHYQN ITKLALSDDD SMVFTASKDG AIHGYLVTEL VSADRDSTVA
PFRKWASHTL AVSDLKITHG SNPRILTTGA DHIACLHSIS MDSVILKASA DRPLTSCAID
SAETRIFIGT EVGNIAQINL FQLGAEERDL LIQAGDEHNT KFRVLNGHSD EITRLTINTD
GTLLASGDAS GKYCIWEISS HQCLKVSTMR STISTLRFIP FWPTISGGEH TKKFRPVWDL
RREPTKCERL AIEVSNEFNA DQKHWNDVIE DSIDQMLLES GSTTSAQLQW QVEAPMRKQA
EVEKAEAEAM AQVITLGDDE DDAPEVGNQR RQNKKNNKKN RKLQKKLEAE QALKNKVIEE
EAELIVIDDG EESNKKILDL QASMTELREE NEKLKEINRQ MYEFVAAEIV DR