PRO1_LEIEN
ID PRO1_LEIEN Reviewed; 567 AA.
AC P13865;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Probable transport protein;
DE Short=LTP;
GN Name=PRO-1;
OS Leishmania enriettii.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5663;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2813352; DOI=10.1073/pnas.86.20.7682;
RA Cairns B.R., Collard M.W., Landfear S.M.;
RT "Developmentally regulated gene from Leishmania encodes a putative membrane
RT transport protein.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:7682-7686(1989).
CC -!- FUNCTION: Probable membrane transport protein.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- DEVELOPMENTAL STAGE: Predominantly found in promastigotes.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; M26229; AAA29256.1; -; Genomic_DNA.
DR PIR; A33974; A33974.
DR AlphaFoldDB; P13865; -.
DR SMR; P13865; -.
DR VEuPathDB; TriTrypDB:CUR178_00672; -.
DR VEuPathDB; TriTrypDB:LENLEM3045_360073900; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR045262; STP/PLT_plant.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23500; PTHR23500; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..567
FT /note="Probable transport protein"
FT /id="PRO_0000050450"
FT TOPO_DOM 1..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..189
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..366
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 388..404
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 426..437
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..458
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 459..480
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 502..514
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 536..567
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 61451 MW; D6F68AAB2AA4B62B CRC64;
MSDRVEVNER RSDSVSEKEP ARDDARKDVT DDQEDAPPFM TANNARVMLV QAIGGSLNGY
SIGFVGVYST LFGYSTNCAS FLQENSCTTV PNADCKWFVS PTGSSYCGWP EVTCRKEYAY
SSPAEMPGAL ARCEADSRCR WSYSDEECQN PSGYSSSESG IFAGSMIAGC LIGSVFAGPL
ASKIGARLSF LLVGLVGVVA SVMYHASCAA DEFWVLIVGR FVIGLFLGVI CVACPVYTDQ
NAHPKWKRTI GVMFQVFTTL GIFVAALMGL ALGQSIRFDH DGDQKVMARM QGLCVFSTLF
SLLTVVLGIV TRESRAKFDG GEEGRAELNP SEYGYVEMIP RLLMGCVMAG TLQLTGINAV
MNYAPTIMGS LGLAPLVGNF VVMLWNFVTT LASIPLSYVF TMRHVFLFGS IFTSCMCLFM
CGIPVYPGVS KKLEAKNGVA ITGILLFILG FEVCVGPCYY VLTQDMFPPS FRPRGASFTQ
VAQFIFNLII NVCYPIATES ISGGPSGNQD KGQAVAFIFF GGLGLICFVI QVFFLHPWDE
ERDGKKVVAP AIGKKELSEE SIGNRAE
