ID   PRO1_NEUCR              Reviewed;         696 AA.
AC   Q9P326; Q7RV89;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Transcriptional regulatory protein pro1;
DE   AltName: Full=Arrested development protein 1;
GN   Name=adv-1; Synonyms=pro1; ORFNames=NCU07392;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND FUNCTION.
RC   STRAIN=FGSC 4317;
RX   PubMed=12081464; DOI=10.1016/s1087-1845(02)00010-5;
RA   Masloff S., Jacobsen S., Poeggeler S., Kueck U.;
RT   "Functional analysis of the C6 zinc finger gene pro1 involved in fungal
RT   sexual development.";
RL   Fungal Genet. Biol. 36:107-116(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: May be involved in fruiting body development.
CC       {ECO:0000269|PubMed:12081464}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; AJ238537; CAB89819.1; -; mRNA.
DR   EMBL; AJ238440; CAB89818.1; -; Genomic_DNA.
DR   EMBL; CM002236; EAA29240.3; -; Genomic_DNA.
DR   RefSeq; XP_958476.3; XM_953383.3.
DR   AlphaFoldDB; Q9P326; -.
DR   SMR; Q9P326; -.
DR   STRING; 5141.EFNCRP00000007336; -.
DR   EnsemblFungi; EAA29240; EAA29240; NCU07392.
DR   GeneID; 3874628; -.
DR   KEGG; ncr:NCU07392; -.
DR   VEuPathDB; FungiDB:NCU07392; -.
DR   HOGENOM; CLU_011522_0_0_1; -.
DR   InParanoid; Q9P326; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR021858; Fun_TF.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF11951; Fungal_trans_2; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..696
FT                   /note="Transcriptional regulatory protein pro1"
FT                   /id="PRO_0000114967"
FT   DNA_BIND        55..82
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   696 AA;  77811 MW;  B6FC1A91F578F800 CRC64;
     MSTQSPNHHE DITKTSSVNM TTTTTTTKTK AAAKAGTNAA PKQKTQMHRR SRTGCYTCRL
     RRKKCDEGSP MCTACKHLGL CCEYKRPMWW SNNDARRKQK DEIKMIIKRK KLSEKSSHTI
     QTSINTPPGL SHSLPTSATF SDPLDRNRSA SIDSHFGFNF NSPQHGQDFA AFATPQIHVN
     GEYMFPPFSP YEIDMKTERQ IFINDIPTLR ESTVSTFSTY QTPPPPGTIL PSFPLEGEWT
     EQVFSERRES LTEETFNANF FDFACDPAMA SSQVAIELDD GDQKLLDHFV QHVLPTIFPI
     LESNQHGSIS SELVLPSLAN NKGYLHCCLS IAAQHFKSTM GIQNEEIDND IMRHRYATIT
     WLCEALNRDE NHQPILDATL GLIFFQCIVG RPEDTLPDIP WHQHFQAVVS LVQKLDLAGL
     VSDITKPLAH TPFNMTLTSW IDILGATMLG SSPLFAHTYR NKHLSINNHS LGLRELMGCE
     DRVMYLISEI ACLESLKNQG MDDITLCQHV RGLGDEISNT EVNEGTLVEP YNANGTLSPK
     QLSKNITAAF RLAARIYLCS LVPGFYPAQP SCMGLVEKLT AVLQLIPSGV NGYDRSLTWV
     YLIGGSVSVP GSSFRDFFEN RVAQLGDVAN SGSFGRMTVL LREVWLQYEA ILAAAEAAAG
     TSSLSSETPQ QQQQVNAHYV RWREVMQIKG WDYLLI