AAAS_ARATH
ID AAAS_ARATH Reviewed; 447 AA.
AC Q8GWR1; Q9LER8;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Aladin {ECO:0000303|PubMed:21189294};
GN Name=AAAS {ECO:0000303|PubMed:21189294};
GN OrderedLocusNames=At3g56900 {ECO:0000312|Araport:AT3G56900};
GN ORFNames=T8M16.230 {ECO:0000312|EMBL:CAC00753.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAC43280.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP IDENTIFICATION IN THE NUCLEAR PORE COMPLEX BY MASS SPECTROMETRY,
RP SUBCELLULAR LOCATION, AND NOMENCLATURE.
RX PubMed=21189294; DOI=10.1105/tpc.110.079947;
RA Tamura K., Fukao Y., Iwamoto M., Haraguchi T., Hara-Nishimura I.;
RT "Identification and characterization of nuclear pore complex components in
RT Arabidopsis thaliana.";
RL Plant Cell 22:4084-4097(2010).
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC). The NPC has an eight-
CC fold symmetrical structure comprising a central transport channel and
CC two rings, the cytoplasmic and nuclear rings, to which eight filaments
CC are attached. The cytoplasmic filaments have loose ends, while the
CC nuclear filaments are joined in a distal ring, forming a nuclear
CC basket. NPCs are highly dynamic in configuration and composition, and
CC can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160
CC subcomplex and the NUP93 subcomplex, containing approximately 30
CC different nucleoporin proteins. {ECO:0000305|PubMed:21189294}.
CC -!- INTERACTION:
CC Q8GWR1; Q8GWK2: At2g41710; NbExp=3; IntAct=EBI-4425567, EBI-25521547;
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:21189294}.
CC Nucleus, nuclear pore complex {ECO:0000305|PubMed:21189294}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC00753.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL390921; CAC00753.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE79584.1; -; Genomic_DNA.
DR EMBL; AK118686; BAC43280.1; -; mRNA.
DR EMBL; BT005366; AAO63430.1; -; mRNA.
DR PIR; T51278; T51278.
DR RefSeq; NP_191249.2; NM_115549.5.
DR AlphaFoldDB; Q8GWR1; -.
DR SMR; Q8GWR1; -.
DR BioGRID; 10173; 5.
DR IntAct; Q8GWR1; 3.
DR STRING; 3702.AT3G56900.1; -.
DR PaxDb; Q8GWR1; -.
DR PRIDE; Q8GWR1; -.
DR ProteomicsDB; 245150; -.
DR EnsemblPlants; AT3G56900.1; AT3G56900.1; AT3G56900.
DR GeneID; 824857; -.
DR Gramene; AT3G56900.1; AT3G56900.1; AT3G56900.
DR KEGG; ath:AT3G56900; -.
DR Araport; AT3G56900; -.
DR TAIR; locus:2103620; AT3G56900.
DR eggNOG; KOG2139; Eukaryota.
DR HOGENOM; CLU_027691_2_1_1; -.
DR InParanoid; Q8GWR1; -.
DR OMA; RGGICIW; -.
DR OrthoDB; 628517at2759; -.
DR PhylomeDB; Q8GWR1; -.
DR PRO; PR:Q8GWR1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8GWR1; baseline and differential.
DR Genevisible; Q8GWR1; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0005635; C:nuclear envelope; IDA:TAIR.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR045139; Aladin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR PANTHER; PTHR14494; PTHR14494; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
PE 1: Evidence at protein level;
KW mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Repeat; Translocation; Transport; WD repeat.
FT CHAIN 1..447
FT /note="Aladin"
FT /id="PRO_0000431092"
FT REPEAT 97..138
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 142..181
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 210..250
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 252..291
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REGION 49..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 48486 MW; 2CDA358350F72BA6 CRC64;
MASFPHPGSV TVCEINRDLI TAQNLSDERA QETYGKVLGM VFSPVSFDST PSSLQENEGQ
ENGDKASGES KGLVATLQMK VADSLKQILQ PTDVTLLSEI DLQGVSWHQG KHIIAFISGA
NQVTIRDYED KDEKEPCILT SDSQRNVKAL EWRPNGGKSL SIACRGGICI WAASYPGNMA
LVRSGGSALR GSLSRGSGTR WILVDFLRCQ NDEQISALSW SPCGRYLASA SYDSSSFTIW
DVSQGAGTPI RRGLGGISML KWSPTGDYFF AARFDGTFCL WETNTWTSEP WSLSSGSGSV
TGAIWDPEGR FILISFSKSS TLGSVHFSSK PPSLDAHLLP VELPEIASLT GCEGIEKIAW
DASGERLAVS YKGGDENYKG LIAIYDTRRT PIVSASLVGF IRGPGENPKA LSFSFHDKFK
QGPLLSVCWS TGFCCTYPLI FRSHVLP
