AAAS_DROME
ID AAAS_DROME Reviewed; 466 AA.
AC Q9W351;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Aladin {ECO:0000303|PubMed:26246606, ECO:0000312|FlyBase:FBgn0030122};
GN Name=Aladin {ECO:0000303|PubMed:26246606, ECO:0000312|FlyBase:FBgn0030122};
GN ORFNames=CG16892 {ECO:0000312|FlyBase:FBgn0030122};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAK93382.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAK93382.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAK93382.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000312|EMBL:ADJ37240.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Carlson J., Booth B., Frise E., Sandler J., Wan K., Yu C., Celniker S.;
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=26246606; DOI=10.1091/mbc.e15-02-0113;
RA Carvalhal S., Ribeiro S.A., Arocena M., Kasciukovic T., Temme A.,
RA Koehler K., Huebner A., Griffis E.R.;
RT "The nucleoporin ALADIN regulates Aurora A localization to ensure robust
RT mitotic spindle formation.";
RL Mol. Biol. Cell 26:3424-3438(2015).
CC -!- FUNCTION: Involved in mitotic spindle assembly.
CC {ECO:0000269|PubMed:26246606}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q9NRG9}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000269|PubMed:26246606}. Note=During mitosis localizes throughout
CC the spindle, is excluded from chromatin, and is enriched on the nuclear
CC envelope remnants that surround the spindle. Present in a ring that
CC surrounds the centrosome in prometaphase and metaphase cells.
CC {ECO:0000269|PubMed:26246606}.
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DR EMBL; AE014298; AAF46484.1; -; Genomic_DNA.
DR EMBL; AE014298; AHN59520.1; -; Genomic_DNA.
DR EMBL; AY051958; AAK93382.1; -; mRNA.
DR EMBL; BT125044; ADJ37240.1; -; mRNA.
DR RefSeq; NP_001285049.1; NM_001298120.1.
DR RefSeq; NP_572557.1; NM_132329.4.
DR AlphaFoldDB; Q9W351; -.
DR SMR; Q9W351; -.
DR IntAct; Q9W351; 7.
DR STRING; 7227.FBpp0071254; -.
DR PaxDb; Q9W351; -.
DR PRIDE; Q9W351; -.
DR DNASU; 31881; -.
DR EnsemblMetazoa; FBtr0071319; FBpp0071254; FBgn0030122.
DR EnsemblMetazoa; FBtr0339949; FBpp0308972; FBgn0030122.
DR GeneID; 31881; -.
DR KEGG; dme:Dmel_CG16892; -.
DR UCSC; CG16892-RA; d. melanogaster.
DR CTD; 31881; -.
DR FlyBase; FBgn0030122; Aladin.
DR VEuPathDB; VectorBase:FBgn0030122; -.
DR eggNOG; KOG2139; Eukaryota.
DR GeneTree; ENSGT00390000009446; -.
DR HOGENOM; CLU_027691_0_1_1; -.
DR InParanoid; Q9W351; -.
DR OMA; RGGICIW; -.
DR OrthoDB; 628517at2759; -.
DR PhylomeDB; Q9W351; -.
DR Reactome; R-DME-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-DME-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-DME-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-DME-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-DME-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-DME-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-DME-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DME-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-DME-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-DME-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-DME-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-DME-8980692; RHOA GTPase cycle.
DR BioGRID-ORCS; 31881; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31881; -.
DR PRO; PR:Q9W351; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030122; Expressed in ovary and 13 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0012505; C:endomembrane system; HDA:FlyBase.
DR GO; GO:0072686; C:mitotic spindle; IDA:UniProtKB.
DR GO; GO:0005643; C:nuclear pore; ISS:FlyBase.
DR GO; GO:0000922; C:spindle pole; IDA:UniProtKB.
DR GO; GO:0001578; P:microtubule bundle formation; IMP:UniProtKB.
DR GO; GO:0090307; P:mitotic spindle assembly; IMP:UniProtKB.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006913; P:nucleocytoplasmic transport; ISS:FlyBase.
DR GO; GO:1902365; P:positive regulation of protein localization to spindle pole body; IMP:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR045139; Aladin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR PANTHER; PTHR14494; PTHR14494; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Repeat; Translocation; Transport;
KW WD repeat.
FT CHAIN 1..466
FT /note="Aladin"
FT /id="PRO_0000447261"
FT REPEAT 135..174
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 179..218
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 229..269
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 271..310
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 378..418
FT /note="WD 5"
FT /evidence="ECO:0000255"
SQ SEQUENCE 466 AA; 52279 MW; D5F77E06455735B0 CRC64;
MAALSNLKQC PPFSTLPDLA LRHNHIPELE RYPQINLNSE LLANPAGQRY YGGQSFVSVN
EGVLKRIARS FFNGGFWKTL EEARSPETRE QAPLIAQAGD LIAQFLGLAT GLRILPHTQQ
LSAERIAQFV ETRDWLNSDV RYLAWNQHFF CLAVAGVDDV VRIYTKSSSA TTATVLKSPS
QTQITCMAWR PLCASEIVIG CRQGLCFWEV DSTLHLGRTN APSEIFKYPN NLPITSMQWN
KDGTQLATAS IGDRSIIIWQ PDTGMMQPLK RLGPPGSLLK WSPDNDWLFA ATVDRVFRVW
NCHQQWTTER WVCGPGGYVQ TACWSPCGRF LLFVSSAEPI LYRLQFVQQS LLSSSADEKE
ILPIADLNAC SIDANRTLVG GPAQQLAWDP HGNYLVVTFK ATNCIAVFRT FIQKFDLQIS
AAYYLSGETA AEHPSFICFQ PLYEDNDRSV LTIAWSSGRI QYYAFD
