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ATG1_COCIM
ID   ATG1_COCIM              Reviewed;         969 AA.
AC   Q1DN93; A0A0D8JX08; I9NMZ5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Serine/threonine-protein kinase ATG1 {ECO:0000250|UniProtKB:P53104};
DE            EC=2.7.11.1 {ECO:0000250|UniProtKB:P53104};
DE   AltName: Full=Autophagy-related protein 1 {ECO:0000250|UniProtKB:P53104};
GN   Name=ATG1 {ECO:0000250|UniProtKB:P53104}; ORFNames=CIMG_08220;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Serine/threonine protein kinase involved in the cytoplasm to
CC       vacuole transport (Cvt) and found to be essential in autophagy, where
CC       it is required for the formation of autophagosomes. Involved in the
CC       clearance of protein aggregates which cannot be efficiently cleared by
CC       the proteasome. Required for selective autophagic degradation of the
CC       nucleus (nucleophagy) as well as for mitophagy which contributes to
CC       regulate mitochondrial quantity and quality by eliminating the
CC       mitochondria to a basal level to fulfill cellular energy requirements
CC       and preventing excess ROS production. Also involved in endoplasmic
CC       reticulum-specific autophagic process, in selective removal of ER-
CC       associated degradation (ERAD) substrates. Plays a key role in ATG9 and
CC       ATG23 cycling through the pre-autophagosomal structure and is necessary
CC       to promote ATG18 binding to ATG9 through phosphorylation of ATG9.
CC       Catalyzes phosphorylation of ATG4, decreasing the interaction between
CC       ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of
CC       ATG8. {ECO:0000250|UniProtKB:P53104}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000250|UniProtKB:P53104};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:P53104};
CC   -!- SUBUNIT: Homodimer. Forms a ternary complex with ATG13 and ATG17.
CC       {ECO:0000250|UniProtKB:P53104}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P53104}.
CC       Preautophagosomal structure membrane {ECO:0000250|UniProtKB:P53104};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:P53104}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC       kinase family. APG1/unc-51/ULK1 subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00159}.
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DR   EMBL; GG704913; KJF60812.1; -; Genomic_DNA.
DR   EMBL; GG704913; KJF60813.1; -; Genomic_DNA.
DR   RefSeq; XP_004445075.1; XM_004445018.1.
DR   RefSeq; XP_004445076.1; XM_004445019.1.
DR   AlphaFoldDB; Q1DN93; -.
DR   SMR; Q1DN93; -.
DR   STRING; 246410.Q1DN93; -.
DR   PRIDE; Q1DN93; -.
DR   EnsemblFungi; KJF60812; KJF60812; CIMG_08220.
DR   EnsemblFungi; KJF60813; KJF60813; CIMG_08220.
DR   GeneID; 4559351; -.
DR   KEGG; cim:CIMG_08220; -.
DR   VEuPathDB; FungiDB:CIMG_08220; -.
DR   InParanoid; Q1DN93; -.
DR   OMA; INNVVQW; -.
DR   OrthoDB; 1084750at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR045269; Atg1-like.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR022708; Ser/Thr_kinase_C.
DR   PANTHER; PTHR24348; PTHR24348; 1.
DR   Pfam; PF12063; DUF3543; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Autophagy; Cytoplasm; Kinase; Membrane; Nucleotide-binding;
KW   Protein transport; Reference proteome; Serine/threonine-protein kinase;
KW   Transferase; Transport.
FT   CHAIN           1..969
FT                   /note="Serine/threonine-protein kinase ATG1"
FT                   /id="PRO_0000317793"
FT   DOMAIN          30..335
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          563..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          880..907
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          941..969
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..377
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        890..904
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        173
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10027"
FT   BINDING         36..44
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         59
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   969 AA;  106042 MW;  BFEC1C5E1941FFE2 CRC64;
     MAALQSPKTS SRRSKGDGDG DTRDVILGKY TKIEEIGRGS FATVYQGIHN KYRSCVAIKA
     VNISSLNPKL KDNLKLEIEI LKGLQHPHIV ALIDCDESTS CIHLVMEYCA LGDLSLFIRK
     RDTLSKHELT RDMIAKYPNP PAGGLNEVIV RHFLKQLASA LQFLRTKDLI HRDLKPQNLL
     LNPPPSTYAK GLLRIVPYKT REDSFTPLVG VESLPMLKIA DFGFARSLPA TSLAETLCGS
     PLYMAPEILR YEKYDAKADL WSVGTVLFEM VVGKSPFRAG NHVDLLRKIE QGEDNIRFPI
     QTEASPPLKK LIRSLLKRNP VERLSFKDFF ESSVVKGNIP GLVDEDLQAQ RERDSRLAAH
     AARRDSLPSR TSDGKLEDRP PSSASSPRPP PSNFTRPATS PAVRHVGSRE NPDLQRVAVK
     ARKASVASVT GSPSKEELRD HNAKGPVTEQ PGPTSPAKER ATTRKNSSDQ RIDDILDSER
     ERAAQDVAFE RDYVVVEKRA VEVNAFADEL AASPRFQQQQ QQQLIPKQAG AIVRRATTTA
     TPQLSSSPRD AMSRAVATAY NRPRTGSTHN RHNSYDRRYG PSPTSATSAI SKALNKASGR
     LFGVSFSPPL ALTKAGRSPP IGYNAFPAYP LAEGNLAVVG DGAKIQPPLD EDTKVLHIIE
     EIATRSDVVY GFAEVKYKQL APLTPSMQAD TAIKPVVSPE VVDTPEANDT GLTVDAIFTL
     SEEALVLYVK ALSLLAKSMD IAGAWWARKN RGETIGNSPN VNVGCRVNNV VQWVRNRFNE
     VLQKAEYSRL KLLDAQRQLP YDHAHHASQV GRVSVGALAH SSDQVVISSG ITAEKLMYDR
     ALEMSRTAAI NELTGEDLPG CEIAYMTAIR MLEAVLDSDE DHQLSGERAG EAANTVSNEE
     NGEVNGLQGE DREIVAKLVA SIRIRLTALK KKIALMTKRT SAPAMVSPAR TPACQPPAAS
     PVVPQASSR
 
 
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