ID   PROA_TRYBB              Reviewed;         115 AA.
AC   P14043;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Procyclic form-specific polypeptide;
DE   AltName: Full=PARP;
DE   AltName: Full=Procyclin;
DE   Flags: Precursor;
GN   Name=PROA;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=227(ILTAT1);
RX   PubMed=2573878; DOI=10.1093/nar/17.21.8727;
RA   Koenig E., Delius H., Carrington M., Williams R.O., Roditi I.;
RT   "Duplication and transcription of procyclin genes in Trypanosoma brucei.";
RL   Nucleic Acids Res. 17:8727-8739(1989).
CC   -!- FUNCTION: Major surface antigen of procyclic forms.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC   -!- DEVELOPMENTAL STAGE: Expressed only at a certain stage during
CC       differentiation in the insect vector.
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DR   EMBL; X16015; CAA34147.1; -; Genomic_DNA.
DR   PIR; S14896; FAUTPC.
DR   AlphaFoldDB; P14043; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008882; Trypano_PARP.
DR   Pfam; PF05887; Trypan_PARP; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Repeat;
KW   Signal.
FT   SIGNAL          1..27
FT   CHAIN           28..93
FT                   /note="Procyclic form-specific polypeptide"
FT                   /id="PRO_0000022109"
FT   PROPEP          94..115
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000022110"
FT   REPEAT          59..60
FT                   /note="1"
FT   REPEAT          61..62
FT                   /note="2"
FT   REPEAT          63..64
FT                   /note="3"
FT   REPEAT          65..66
FT                   /note="4"
FT   REPEAT          67..68
FT                   /note="5"
FT   REPEAT          69..70
FT                   /note="6"
FT   REPEAT          71..72
FT                   /note="7"
FT   REPEAT          73..74
FT                   /note="8"
FT   REPEAT          75..76
FT                   /note="9"
FT   REPEAT          77..78
FT                   /note="10"
FT   REPEAT          79..80
FT                   /note="11"
FT   REPEAT          81..82
FT                   /note="12"
FT   REPEAT          83..84
FT                   /note="13"
FT   REPEAT          85..86
FT                   /note="14"
FT   REPEAT          87..88
FT                   /note="15"
FT   REPEAT          89..90
FT                   /note="16"
FT   REPEAT          91..92
FT                   /note="17"
FT   REGION          27..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..92
FT                   /note="17 X 2 AA tandem repeats of [DE]-P"
FT   COMPBIAS        34..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..88
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           93
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  11714 MW;  6D39F0731CF0509E CRC64;
     MAPRSLYLLA VLLFSANLFA GVGFAAAAEG PEDKGLTKGG KGKGEKGTKV GADDTNGTDP
     DPEPEPEPEP EPEPEPEPEP EPEPEPEPEP EPGAATLKSV ALPFAIAAAA LVAAF