ATG22_CANAL
ID ATG22_CANAL Reviewed; 500 AA.
AC Q5A6K2; A0A1D8PSS7;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 2.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Autophagy-related protein 22;
GN Name=ATG22; OrderedLocusNames=CAALFM_CR04610CA;
GN ORFNames=CaO19.552, CaO19.8187;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: May be required for lysis of autophagic vesicles after
CC delivery to the vacuole. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Vacuole and punctate structures.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ATG22 family. {ECO:0000305}.
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DR EMBL; CP017630; AOW31197.1; -; Genomic_DNA.
DR RefSeq; XP_717415.2; XM_712322.2.
DR AlphaFoldDB; Q5A6K2; -.
DR SMR; Q5A6K2; -.
DR GeneID; 3640951; -.
DR KEGG; cal:CAALFM_CR04610CA; -.
DR CGD; CAL0000198702; orf19.8187.
DR VEuPathDB; FungiDB:CR_04610C_A; -.
DR eggNOG; ENOG502QTIR; Eukaryota.
DR HOGENOM; CLU_034559_0_0_1; -.
DR InParanoid; Q5A6K2; -.
DR OrthoDB; 1119570at2759; -.
DR PRO; PR:Q5A6K2; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR024671; Atg22-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF11700; ATG22; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 3: Inferred from homology;
KW Autophagy; Glycoprotein; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..500
FT /note="Autophagy-related protein 22"
FT /id="PRO_0000207619"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 14
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 500 AA; 56529 MW; C17DD6EB2F2AD93F CRC64;
MKVNHNHISN TGVNDSEDIL EAQDEISIDN NKNQENIWNK KSIFHTWLLL CYSTGPVASM
SRTYIPASIQ SIAKNVGKTK MNQPCGTQGN DCYVKFGFMT VHHTSYVLYL RAVSTAIEGV
VAIFLMGIAD YSNYRKSFLI FSILVYGFLA LPFIGLTNND YQTLVLASIL YSLLIIDDSI
YQILEGSYIP LFMRADKKNP MQRGSVVAVL GLFLGNLGGI TALVIGIIIS YLSGTPESKG
YHNFLLAITI AGCLTIGLSL FSALYIPNVQ GKQRIDNFLV LPFKRFFNLL KDIQKYPMAF
LYCISWVIWN VSFNNFMSMF LLLFRSTLGL GNSDAEYTVY TFMSYICSSW GSLVWMFLYQ
KWNSNIKYWG YSFLSVSLLA NFWGCLGIHK LTPLGYQNRW EFWVFEVFYS ATSSAMRSLN
RCVYSSLLPE GNEAQYFGLE VTLGIASGWI GGLVNAVIQD RTNDDRFPFL PNMFLVVVSL
IVYYYVDLQK GKNDVNNGNS