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ATG22_CANAL
ID   ATG22_CANAL             Reviewed;         500 AA.
AC   Q5A6K2; A0A1D8PSS7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Autophagy-related protein 22;
GN   Name=ATG22; OrderedLocusNames=CAALFM_CR04610CA;
GN   ORFNames=CaO19.552, CaO19.8187;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: May be required for lysis of autophagic vesicles after
CC       delivery to the vacuole. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Note=Vacuole and punctate structures.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG22 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31197.1; -; Genomic_DNA.
DR   RefSeq; XP_717415.2; XM_712322.2.
DR   AlphaFoldDB; Q5A6K2; -.
DR   SMR; Q5A6K2; -.
DR   GeneID; 3640951; -.
DR   KEGG; cal:CAALFM_CR04610CA; -.
DR   CGD; CAL0000198702; orf19.8187.
DR   VEuPathDB; FungiDB:CR_04610C_A; -.
DR   eggNOG; ENOG502QTIR; Eukaryota.
DR   HOGENOM; CLU_034559_0_0_1; -.
DR   InParanoid; Q5A6K2; -.
DR   OrthoDB; 1119570at2759; -.
DR   PRO; PR:Q5A6K2; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR024671; Atg22-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF11700; ATG22; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Autophagy; Glycoprotein; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Vacuole.
FT   CHAIN           1..500
FT                   /note="Autophagy-related protein 22"
FT                   /id="PRO_0000207619"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        438..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   500 AA;  56529 MW;  C17DD6EB2F2AD93F CRC64;
     MKVNHNHISN TGVNDSEDIL EAQDEISIDN NKNQENIWNK KSIFHTWLLL CYSTGPVASM
     SRTYIPASIQ SIAKNVGKTK MNQPCGTQGN DCYVKFGFMT VHHTSYVLYL RAVSTAIEGV
     VAIFLMGIAD YSNYRKSFLI FSILVYGFLA LPFIGLTNND YQTLVLASIL YSLLIIDDSI
     YQILEGSYIP LFMRADKKNP MQRGSVVAVL GLFLGNLGGI TALVIGIIIS YLSGTPESKG
     YHNFLLAITI AGCLTIGLSL FSALYIPNVQ GKQRIDNFLV LPFKRFFNLL KDIQKYPMAF
     LYCISWVIWN VSFNNFMSMF LLLFRSTLGL GNSDAEYTVY TFMSYICSSW GSLVWMFLYQ
     KWNSNIKYWG YSFLSVSLLA NFWGCLGIHK LTPLGYQNRW EFWVFEVFYS ATSSAMRSLN
     RCVYSSLLPE GNEAQYFGLE VTLGIASGWI GGLVNAVIQD RTNDDRFPFL PNMFLVVVSL
     IVYYYVDLQK GKNDVNNGNS
 
 
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