ID   ATG22_CHAGB             Reviewed;         650 AA.
AC   Q2HFE0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Autophagy-related protein 22;
GN   Name=ATG22; ORFNames=CHGG_01064;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Vacuolar effluxer which mediate the efflux of amino acids
CC       resulting from autophagic degradation. The release of autophagic amino
CC       acids allows the maintenance of protein synthesis and viability during
CC       nitrogen starvation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Note=Vacuole and punctate structures.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG22 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAQ92829.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH408029; EAQ92829.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001220285.1; XM_001220284.1.
DR   AlphaFoldDB; Q2HFE0; -.
DR   STRING; 38033.XP_001220285.1; -.
DR   EnsemblFungi; EAQ92829; EAQ92829; CHGG_01064.
DR   GeneID; 4386459; -.
DR   eggNOG; ENOG502QR9I; Eukaryota.
DR   HOGENOM; CLU_017518_1_1_1; -.
DR   InParanoid; Q2HFE0; -.
DR   OrthoDB; 1460747at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032974; P:amino acid transmembrane export from vacuole; IEA:InterPro.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   CDD; cd17483; MFS_Atg22_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR044738; Atg22.
DR   InterPro; IPR024671; Atg22-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF11700; ATG22; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Autophagy; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport; Vacuole.
FT   CHAIN           1..650
FT                   /note="Autophagy-related protein 22"
FT                   /id="PRO_0000318024"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        449..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        484..504
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        518..538
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        557..577
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        586..606
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          36..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          628..650
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        311
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        344
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   650 AA;  71001 MW;  8B1C8B66A88734BE CRC64;
     MVPRNDPEAG RPPLAPRLFS RFSQLSKHSF LSYSSSFEAD DERSSTGSLE NFGIMSPGRS
     RSNSGSGSSS FGALPPRYPG DDTRPTSPKE LAGWYAYAFA AEVYVICGSF IPILLESLAR
     ENGVLLSDRK TPCGSSSDKN GDNGGQCIVY VLGMEINTAS FAMYTFSISV LIQALLVVSI
     SCAADHGNYR KKLLLAFGWI GSIAVMLYIF VSKNLYIFGA LLAIVSNTSF GASFVLLNSF
     LPLLVRHHPE IIDKEANIVP NGQDAQDHED LDGETAMADS TAALLPRGSL EDGNALSRVQ
     TREELTSHEL NLSTQVSAKG IGIGYIAGLF LQCVAIFILI QMKNTTWSQR VVLFVIGAWW
     AIFTVPAAMW LRPRPGPPLP ASSRHTGIRA FIAYTFYAWK SLFRTVQLAR RLVDIMLFLG
     GWFLLSDAIA TTSSTAILFA KTQLHMEPWA LGMINVISTA AGITGAFSWS YISRRLHLQA
     HQTILACIAL FEIIPLYGLL GYLPFVKNWG VFGLQQPWEM YPLAAVYGFV LGGLSGYCRS
     LYGELIPPGS EAAFYALYAI TDKGSSVFGP AIVGAIIDAS GEIRPAFWFL AAIVGLPAPL
     IWCINVERGR SEGEKLAEVI EGFKVTRSPE RESDEESRAI LDVYDEETDR