ID   ATG22_CRYNB             Reviewed;         546 AA.
AC   P0CM33; Q55QA3; Q5KFW2;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Autophagy-related protein 22;
GN   Name=ATG22; OrderedLocusNames=CNBF4340;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Vacuolar effluxer which mediate the efflux of amino acids
CC       resulting from autophagic degradation. The release of autophagic amino
CC       acids allows the maintenance of protein synthesis and viability during
CC       nitrogen starvation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Note=Vacuole and punctate structures.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG22 family. {ECO:0000305}.
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DR   EMBL; AAEY01000032; EAL20108.1; -; Genomic_DNA.
DR   RefSeq; XP_774755.1; XM_769662.1.
DR   AlphaFoldDB; P0CM33; -.
DR   EnsemblFungi; EAL20108; EAL20108; CNBF4340.
DR   GeneID; 4936986; -.
DR   KEGG; cnb:CNBF4340; -.
DR   VEuPathDB; FungiDB:CNBF4340; -.
DR   HOGENOM; CLU_017518_1_0_1; -.
DR   Proteomes; UP000001435; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032974; P:amino acid transmembrane export from vacuole; IEA:InterPro.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   CDD; cd17483; MFS_Atg22_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR044738; Atg22.
DR   InterPro; IPR024671; Atg22-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF11700; ATG22; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Autophagy; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Vacuole.
FT   CHAIN           1..546
FT                   /note="Autophagy-related protein 22"
FT                   /id="PRO_0000410018"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        473..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        503..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          160..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..185
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   546 AA;  58945 MW;  3F45E4A3430108A4 CRC64;
     MPPPHVRAWY SYAFAAEVFS SYPSGNIPAN HFGTCDGKAL QSSDPRGMDR YSFVQSSSMY
     VKSIAVACQA ICIISIGPLA DIAYWRKRLL LTFAYSGSLS GILFLLFPPL PYAWTPIMAA
     ILNIVGNATY STSIVCSNAF LPGLAKEDVD VQKAWEEATS EGLQDGLRDV HEDTDEENTG
     SVSREDEATH LLPDRLIPAV CAISTQDLAL SDPLAKLIEP SNAKKHYESR LSLTTSRLSS
     TGTAIGFFSG VSVLTLLLIP VTALGGSTFS MRLAIGLSGV WWALFTVPTC IGLPGGAPGH
     GSDFSASQVK KAWVKIGKMV APKQIHQLPN LYIFLLAWIF LSDGFHTTTY AAILYASSVL
     SMSAPKIILV GILVQLAAVV SSVLVPRVQR RLSTTSSKPV TNYKVLLAGV VAAAFIPVYT
     CAGLVLPFGG LRSEGEMYVL AVWFGLVFGP FLSYSRAVYA ELIPPGHEST FFSLFAFTDK
     SASFIGPAAV GLISDLTGNI RYGFLFLLVM LVVPIPVLGR VAVERGRREA VEWAERSRKE
     MSDERV