ID   ATG22_VANPO             Reviewed;         520 AA.
AC   A7TFA9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Autophagy-related protein 22;
GN   Name=ATG22; ORFNames=Kpol_2000p102;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Vacuolar effluxer which mediate the efflux of amino acids
CC       resulting from autophagic degradation. The release of autophagic amino
CC       acids allows the maintenance of protein synthesis and viability during
CC       nitrogen starvation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Note=Vacuole and punctate structures.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG22 family. {ECO:0000305}.
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DR   EMBL; DS480382; EDO19134.1; -; Genomic_DNA.
DR   RefSeq; XP_001646992.1; XM_001646942.1.
DR   AlphaFoldDB; A7TFA9; -.
DR   STRING; 436907.A7TFA9; -.
DR   EnsemblFungi; EDO19134; EDO19134; Kpol_2000p102.
DR   GeneID; 5547464; -.
DR   KEGG; vpo:Kpol_2000p102; -.
DR   eggNOG; ENOG502QR9I; Eukaryota.
DR   HOGENOM; CLU_017518_1_0_1; -.
DR   InParanoid; A7TFA9; -.
DR   OMA; MYPLGAV; -.
DR   OrthoDB; 1460747at2759; -.
DR   PhylomeDB; A7TFA9; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032974; P:amino acid transmembrane export from vacuole; IEA:InterPro.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   CDD; cd17483; MFS_Atg22_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR044738; Atg22.
DR   InterPro; IPR024671; Atg22-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF11700; ATG22; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Autophagy; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport; Vacuole.
FT   CHAIN           1..520
FT                   /note="Autophagy-related protein 22"
FT                   /id="PRO_0000318035"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        483..503
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        11
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        193
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        280
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   520 AA;  58470 MW;  FA03727FFB26E7FD CRC64;
     MRYGTLGEEI NTTEVTDEFE TLQTIKRTKQ NIVGWYFYSF SSEPFVVSAI ATYIPLLLEQ
     FARHNGVTLE DHSVHCTADH DKCVLGLFSN RIYIDTSSFA LYTFSVSVFF QTLVVITVSG
     VVDIWNTVTF KRNVLLLFGI IGALSTILIS RIYNTQYYML AFLCILSNSC YGVVNVVGNS
     LLPLFVSEYL QHNSSSLDER DNVDILTTLI SGRGASIGYS SALVVQIISI FLIKKSKSSE
     NIQVATLFVG IWWLIWQLPM SWLLQDSPIS ADVTPEDMDN LSIHKPKKWI FKFSNLKHGW
     SSLFQALKHA KLLKDVVIFL VGWFIVSDSV TTINSTAILF AKTELKMSTL SLIVLSILTM
     INAILGAFTI PQFISRKFQL PGEKLLIYII LWASFIPFYG ILGFVFKNIG LKHKFEMFIT
     AIWYGISLGG LSAVSRSVFS LIIPRGQEST FFSIFNVTDK GSSILGPLLI GLITDYTHDI
     RYSFFLLFAL LILAIPIFHL LDVERGKKEA SSLQKIPIAD