ID   ATG23_ASHGO             Reviewed;         407 AA.
AC   Q756Z7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Autophagy-related protein 23;
GN   Name=ATG23; OrderedLocusNames=AER116C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for cytoplasm to vacuole transport (Cvt) vesicle
CC       formation and efficient autophagy. Plays a role in ATG protein
CC       retrieval from the pre-autophagosomal structure (PAS) and is especially
CC       required for autophagy-dependent cycling of ATG9. Also plays a role in
CC       regulation of filamentous growth (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG23 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52800.1; -; Genomic_DNA.
DR   RefSeq; NP_984976.1; NM_210330.2.
DR   AlphaFoldDB; Q756Z7; -.
DR   SMR; Q756Z7; -.
DR   STRING; 33169.AAS52800; -.
DR   PRIDE; Q756Z7; -.
DR   EnsemblFungi; AAS52800; AAS52800; AGOS_AER116C.
DR   GeneID; 4621181; -.
DR   KEGG; ago:AGOS_AER116C; -.
DR   eggNOG; ENOG502RZQ0; Eukaryota.
DR   HOGENOM; CLU_051067_0_0_1; -.
DR   InParanoid; Q756Z7; -.
DR   OMA; EMSEMIN; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..407
FT                   /note="Autophagy-related protein 23"
FT                   /id="PRO_0000064723"
FT   COILED          74..101
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   407 AA;  45830 MW;  3FC13DE440E50D48 CRC64;
     MNHERILEKR ETILQYCHRL TEMHRAALFD EEESPRNLSL QQLRKNIHIC LKDLCRLNTW
     LTEQDGGFRK ALGSLERYES KLAALLAKER QLGEERQAWE AAVPAGAGDD SGGVFTVHGG
     HQRHLNAYIE SMGVDNTGLG KEPDALPRLS RQQALGHVAV LRLAQAAVSR EISQAEGLLK
     SFRKDQTFIK AELAKLEAFV RAQKLAVERE LEGVRRSQEH IFRKIGLLKL PAREREPLGL
     GRRPAADLES MKAQMEEFLH VRKSALKAML SEHKQETQLL KSQQEVWKEV TTLVEDLEDR
     IRTRFATAAK VDPVELRRLI TDAITQIKSL HYEESYPDVL TCIRDEIAAL EKANDQLPFS
     KQKSITDKLV PVNTGAGFLV NSTSPPKVGL TKSIVPSSSM ATNKKSV