ID   ATG23_DEBHA             Reviewed;         905 AA.
AC   Q6BHF8; B5RUV4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Autophagy-related protein 23;
GN   Name=ATG23; OrderedLocusNames=DEHA2G18942g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for cytoplasm to vacuole transport (Cvt) vesicle
CC       formation and efficient autophagy. Plays a role in ATG protein
CC       retrieval from the pre-autophagosomal structure (PAS) and is especially
CC       required for autophagy-dependent cycling of ATG9. Also plays a role in
CC       regulation of filamentous growth (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG23 family. {ECO:0000305}.
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DR   EMBL; CR382139; CAR65998.1; -; Genomic_DNA.
DR   RefSeq; XP_002770666.1; XM_002770620.1.
DR   AlphaFoldDB; Q6BHF8; -.
DR   SMR; Q6BHF8; -.
DR   STRING; 4959.XP_002770666.1; -.
DR   PRIDE; Q6BHF8; -.
DR   EnsemblFungi; CAR65998; CAR65998; DEHA2G18942g.
DR   GeneID; 8999249; -.
DR   KEGG; dha:DEHA2G18942g; -.
DR   VEuPathDB; FungiDB:DEHA2G18942g; -.
DR   eggNOG; ENOG502QV33; Eukaryota.
DR   HOGENOM; CLU_346116_0_0_1; -.
DR   InParanoid; Q6BHF8; -.
DR   OMA; MNSATHD; -.
DR   OrthoDB; 1468600at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR024312; TACC_fungi.
DR   Pfam; PF12709; Fungal_TACC; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..905
FT                   /note="Autophagy-related protein 23"
FT                   /id="PRO_0000064725"
FT   REGION          18..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          879..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          400..810
FT                   /evidence="ECO:0000255"
FT   COILED          844..882
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        44..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..115
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   905 AA;  103040 MW;  719091DBE9DB830A CRC64;
     MTSPLRFEAD MSMIEGEKLS PIKIPPSRLS TNTTSPDILA KHPHGLSAKQ DARRNTVHNE
     TPKGLTATPL TKKAEPLYSV NKRIPLTSPR ATNQPNLDSL KKSKTKLDAR LYELKSSSRH
     GSPSNKENMH NSGKSTQASQ LSSDVNSSIS HKSPFESSPS KIDTPIKQIN SSFAKNVKSS
     PPKSSPSKAD KRSIEDDSVI ENSRKIAKVI TNANESEVSH HKSDDEHSIQ IDQVFNKEDL
     VGRFSSGASP AKLHEPTVID EDSDGDIYNN EVNTSHTMTS KMRGNESTQL SRIIKITDEV
     DYVTPQRYTE PVAKSPEINQ QHRIKENVIN NTESKETISP LKNHMLSVNS DQKENHVSSN
     RMEDENSDGF NELEDEPTIN FLLSPNSKPV FSLDHIKKVQ DDHFKEVANL EEVINNKNQE
     ILKFSEELSA TNNKFLIYDQ KIKELKQDKK KLIANENLLL IQLKHNEREL ASMTKALRIK
     ENTVTQLESR LSKSKSKYES TANELESVIE EGNTLREQIK RLEKSVEDKS ISQKEYESQI
     KILNDEIKEK DTEISSLTDA NIDYNIKVEN LLSEKEELLT ETGRLGRENN GLEEINSKQQ
     ELLEELDKLE NLAKDKIMTL ENTLDSKTQE IKQVMTEKNE LLTKIDNLTE ENKNSGRELQ
     QYKDDVEELT NKLNNYNNAR SDLDDKINRL QEGLNKSNEA NESLQNKVSG LLEEIERLNQ
     HVSESETQMD LLKSINTEKD EIISGDTKKM GELVQKVNKQ KQVIADYEKD YSKALEDIKS
     LQSKGENTSL NDEIEDLKKQ VSQGQAKTNA RIQEVAEQLY FEYSKKHELK VNQVRASFKK
     QIDNLHFEKK SQARDIDSLQ KKLEIVNMEK NQLLRLIDEY QSGSDHNPKK KLSPKKSGIK
     KPSRY