ID   ATG23_KLULA             Reviewed;         426 AA.
AC   Q6CWA7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Autophagy-related protein 23;
GN   Name=ATG23; OrderedLocusNames=KLLA0B05533g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for cytoplasm to vacuole transport (Cvt) vesicle
CC       formation and efficient autophagy. Plays a role in ATG protein
CC       retrieval from the pre-autophagosomal structure (PAS) and is especially
CC       required for autophagy-dependent cycling of ATG9. Also plays a role in
CC       regulation of filamentous growth (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG23 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382122; CAH02175.1; -; Genomic_DNA.
DR   RefSeq; XP_451782.1; XM_451782.1.
DR   AlphaFoldDB; Q6CWA7; -.
DR   SMR; Q6CWA7; -.
DR   STRING; 28985.XP_451782.1; -.
DR   EnsemblFungi; CAH02175; CAH02175; KLLA0_B05533g.
DR   GeneID; 2897432; -.
DR   KEGG; kla:KLLA0_B05533g; -.
DR   eggNOG; ENOG502RZQ0; Eukaryota.
DR   HOGENOM; CLU_051067_0_0_1; -.
DR   InParanoid; Q6CWA7; -.
DR   OMA; EMSEMIN; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..426
FT                   /note="Autophagy-related protein 23"
FT                   /id="PRO_0000064726"
FT   COILED          64..101
FT                   /evidence="ECO:0000255"
FT   COILED          165..230
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   426 AA;  49037 MW;  9337C9C471A66A6D CRC64;
     MDLNDLLLQQ QEVTNLLSNL QEAHKRILIS NEDENNDLNK IRKDILICLN DLKTVNSLII
     DPRDGLIKKN LHKLEKYEQE LRSLESEEAA IESNLNQWKI DQDPENVRRK ENWGTVPINL
     VGNHQYLLES YVNEVGIENT TLANTNGNHE ETPNSSKFTR EQLLRNARKL KLCQEQVNSE
     IDQLKSLISQ YERDRNVIND EYNRTTELIQ KEVNTLSREE DKINSQREKI LKKLGLLKDH
     EQNQPRNFFF SLGALARVDN SDFKIALSQA YEFIDAKKQA LKKILHENKS QTMSLEHNFS
     IWNDVIRSIQ GLETNLQQSF IEKEGNVPKT DITSMISRTL SRVNSIVGTY SKDSIFTSIL
     CELKALQKAL DELNGKMQPI PIKSSAKTPE LLQMGKSPPK VALSKEYASN LHESTEDFPL
     KINKTD