ID   ATG23_VANPO             Reviewed;         491 AA.
AC   A7TMC5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Autophagy-related protein 23;
GN   Name=ATG23; ORFNames=Kpol_520p42;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Required for cytoplasm to vacuole transport (Cvt) vesicle
CC       formation and efficient autophagy. Plays a role in ATG protein
CC       retrieval from the pre-autophagosomal structure (PAS) and is especially
CC       required for autophagy-dependent cycling of ATG9. Also plays a role in
CC       regulation of filamentous growth (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG23 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS480421; EDO16619.1; -; Genomic_DNA.
DR   RefSeq; XP_001644477.1; XM_001644427.1.
DR   AlphaFoldDB; A7TMC5; -.
DR   SMR; A7TMC5; -.
DR   STRING; 436907.A7TMC5; -.
DR   EnsemblFungi; EDO16619; EDO16619; Kpol_520p42.
DR   GeneID; 5544782; -.
DR   KEGG; vpo:Kpol_520p42; -.
DR   eggNOG; ENOG502RZQ0; Eukaryota.
DR   HOGENOM; CLU_555738_0_0_1; -.
DR   InParanoid; A7TMC5; -.
DR   OMA; EMSEMIN; -.
DR   PhylomeDB; A7TMC5; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..491
FT                   /note="Autophagy-related protein 23"
FT                   /id="PRO_0000318037"
FT   REGION          167..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          412..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          287..397
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   491 AA;  56840 MW;  F15FB31B1EBDE822 CRC64;
     MKNQINKLDD ILLQQQHTND YLLELVKFHN NLLHDNLTSI ENLNLTRKKI LDCFNDLFNL
     NSIIINYHGD IKLEIKNLKE IIIKFNKLNK LEIFYQNKLN QWKSSKVKQI QSASSTNNKI
     TINCNYQPLL KTYLNQIDPD ESTLSNQFNS NLSINDEKLI YTNESFTEDE DDTGDEDNDI
     DHSNNHTNND EDPFLILSNI KLLENCQSTI KADINQLEFL LSNYKKDLKF IENELNSQNL
     KTKYNITLMQ EKLDKINIKR KKLLIKIGLS KNKNLTSVLD KDEKIIIENI NDFINSKINS
     LNDQLSNKKE NSIVLNQKIN LWEQVINQLN DLENSLKIYL SKNKKKKSID YNIMIEWIND
     TINNLNDIID STDIQLLRNL IENEKKVLVQ ATNELKLNLT PVNSKINDSI SKSINNNNNT
     NITTNTSINN NNNTNENSLL DSSQFQSSKN PFPNIGTSPP KISISEHIAS NNSFTTFQLN
     NTSNDKLMKN E